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SMARCB1/INI-1-Deficient sinonasal carcinoma demonstrates a poor prognosis but favorable clinical outcomes after PD-1/PD-L1 inhibitor therapy: A case series.
Sci Prog
January 2025
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Despite advances in multimodal cancer therapy, such as combining radical surgery with high-intensity chemoradiotherapy, for SMARCB1/INI-1-deficient sinonasal carcinoma (SDSC), the prognosis of patients remains poor. Immunotherapy is gaining increasing popularity as a novel treatment strategy for patients with SMARCB1/INI-1-deficient tumors. Herein, we report on the management of three patients with SDSC who received PD-1/PD-L1 inhibitor therapy as a part of multimodal therapy based on surgery and chemoradiotherapy.
View Article and Find Full Text PDFWhen the Gleam of Obstruction Isn't Just Stones: A Case Report of Intraductal Papillary Neoplasm of the Bile Duct (IPNB) and the Role of Cholangioscopy in Its Management.
Cureus
December 2024
Gastroenterology and Hepatology, Aberdeen Royal Infirmary Hospital, Aberdeen, GBR.
Intraductal papillary neoplasm of the bile duct (IPNB) is a precursor lesion to biliary tract carcinoma. It is characterised by papillary growth within the bile ducts. The diagnosis and management of IPNB are challenging due to its varying presentations and overlapping features with other biliary diseases.
View Article and Find Full Text PDFCongenital Hydronephrosis Due to Pyeloureteral Atresia: A Case Report.
Cureus
December 2024
Radiology, The Second Health Cluster, Jeddah, SAU.
Intussusception is a leading cause of acute intestinal obstruction in infants, typically presenting with a classic triad of intermittent abdominal pain, vomiting, and currant jelly stools. However, atypical presentations can lead to diagnostic delays, increasing the risk of complications. This report describes a seven-month-old male with an unusual presentation of lethargy and irritability, without overt gastrointestinal symptoms.
View Article and Find Full Text PDFDelayed Neurological Deficits Following Lumbar 1 Burst Fracture: A Diagnostic Challenge Without Radiological Correlates.
Cureus
December 2024
Department of Orthopedics, Spine Unit, Hospital Sungai Buloh, Sungai Buloh, MYS.
Spinal cord injuries, including rare cases without radiological abnormalities, pose diagnostic challenges, particularly in cases of delayed neurological deficit development. This case report describes a 55-year-old man with a stable L1 burst fracture who developed delayed neurological deficits two weeks after sustaining a fall despite no evidence of intrinsic or extrinsic spinal cord abnormalities on magnetic resonance imaging (MRI). The patient initially presented with back pain, normal muscle strength across all myotomes, and imaging that showed no canal stenosis or retropulsion fragments.
View Article and Find Full Text PDFMonkeypox in an Immunocompromised Patient: A Case Report.
Cureus
December 2024
Radiology Department, Universidad Internacional del Ecuador, Quito, ECU.
Monkeypox (Mpox) was declared a public health emergency in 2022. The most common form of presentation is a self-limited illness associated with a skin rash. However, immunocompromised patients may present with more severe forms of the disease.
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