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Effect of gut microbiota changes on cytokines IL-10 and IL-17 levels in liver transplantation patients.
BMC Infect Dis
January 2025
Botany and Microbiology Department, Faculty of Science, Menoufia University, Shebeen El-Kom, Egypt.
Background: Liver transplantation (LT) is a critical intervention for individuals with end-stage liver disease; yet, post-transplant problems, especially infections, graft rejection, and chronic liver disease, are often linked to systemic inflammation. Cytokines, small signaling molecules, significantly influence immune responses during and post-liver transplantation. Nonetheless, the intricate relationships among cytokines, immune responses, and the gut microbiota, especially gut dysbiosis, are still inadequately comprehended.
View Article and Find Full Text PDFZika virus modulates human fibroblasts to enhance transmission success in a controlled lab-setting.
Commun Biol
January 2025
Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Transmission of Zika virus (ZIKV) has been reported in 92 countries and the geographical spread of invasive virus-borne vectors has increased in recent years. Arboviruses naturally survive between vertebrate hosts and arthropod vectors. Transmission success requires the mosquito to feed on viraemic hosts.
View Article and Find Full Text PDFKidney immunology from pathophysiology to clinical translation.
Nat Rev Immunol
January 2025
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kidney diseases are widespread and represent a considerable medical, social and economic burden. However, there has been marked progress in understanding the immunological aspects of kidney disease. This includes the identification of distinct intrarenal immunological niches and characterization of kidney disease endotypes according to the underlying molecular immunopathology, as well as a better understanding of the pathological roles for T cells, mononuclear phagocytes and B cells and the renal elements they target.
View Article and Find Full Text PDFInfluence of plasma exosomes from women living with HIV Stratified by HAND on monocyte subpopulations from healthy women without HIV.
J Neurovirol
January 2025
Department of Pharmacology and Toxicology, Medical Sciences Campus, University of Puerto Rico, San Juan, 00936-5067, Puerto Rico.
The role of plasma exosomes from people living with HIV (PLWH) with HAND in the phenotypic profile of uninfected monocytes remains unknown. We hypothesized that these exosomes influence the CD14/CD16 phenotypical profile of uninfected monocytes in a time-dependent manner. Exosomes were collected via ultracentrifugation from the plasma of women living with HIV (WLWH) and healthy controls stratified according to their cognition into normal cognition (NC) or symptomatic neurocognitive impairment (SNI) groups.
View Article and Find Full Text PDFDoes the use of engorged adult ticks of Rhipicephalus microplus as substrate modifies the acaricidal behavior of Metarhizium anisopliae?
Exp Appl Acarol
January 2025
Centro de Enseñanza, Investigación, y Extensión en Ganadería Tropical, Facultad de Medicina Veterinaria y Zootecnia, Universidad, Nacional Autónoma de México, CDMX, México.
Entomopathogenic fungi (EPF) is one of the most promising alternatives to regulate tick populations. However, these fungi may lose acaricidal effectiveness over time, due to the storage period and/or successive cultivation on artificial media. It is known that using arthropod pests as a substrate for EPF could potentially alter their acaricidal behavior over time, however, studies using ticks for this purpose are scarce.
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