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Pain perception while listening to thrash heavy metal vs relaxing music at a heavy metal festival - the CoPainHell study - a factorial randomized non-blinded crossover trial.
Scand J Pain
January 2024
Department of Anesthesiology, Center for Cancer, and Organ Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Objectives: Music festivals are often a source of joy, but also a risk of injury. While previous studies suggest music can relieve pain, its effect has not been tested in festival settings, nor has the effect of high-energy vs soothing music been compared. We hypothesized that guests at a heavy metal music festival would experience less pain when listening to thrash heavy metal compared to relaxing music, with the effect being influenced by music preference and increased with higher alcohol intake.
View Article and Find Full Text PDFExplainable machine learning for early prediction of sepsis in traumatic brain injury: A discovery and validation study.
PLoS One
November 2024
Department of Trauma Center/Emergency Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Background: People with traumatic brain injury (TBI) are at high risk for infection and sepsis. The aim of the study was to develop and validate an explainable machine learning(ML) model based on clinical features for early prediction of the risk of sepsis in TBI patients.
Methods: We enrolled all patients with TBI in the Medical Information Mart for Intensive Care IV database from 2008 to 2019.
Hypertension induced by peri-pubertal protein restriction depends on renin-angiotensin system dysfunction in adult male rats.
Nutr Metab Cardiovasc Dis
September 2024
Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Parana, Brazil; Adventist College of Parana, Ivatuba, Parana, Brazil. Electronic address:
Background And Aims: Hypertension depends on renin-angiotensin system dysfunction; however, little is known about its implications in the outcomes of neurogenic hypertension induced by peri-pubertal insults. This study aimed to evaluate whether hypertension induced by a peri-pubertal low-protein diet is related to renin-angiotensin system dysfunction in adult male Wistar rats.
Methods And Results: Thirty-day-old male Wistar rats were fed a low-protein diet (4 % casein) for 30 days and subsequently fed a 20.
Predicting Clostridioides difficile infection outcomes with explainable machine learning.
EBioMedicine
August 2024
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
Background: Clostridioides difficile infection results in life-threatening short-term outcomes and the potential for subsequent recurrent infection. Predicting these outcomes at diagnosis, when important clinical decisions need to be made, has proven to be a difficult task.
Methods: 52 clinical features from existing models or the literature were collected retrospectively within ±48 h of diagnosis among 1660 inpatient infections.
Preoperative Echocardiogram Does Not Contribute to Surgical Risk Assessment in Patients With Large Curve Scoliosis and No Cardiac Risk Factors.
J Pediatr Orthop
August 2024
Department of Orthopaedic Surgery.
Objective: Severe scoliosis can affect thoracic organs, potentially leading to cardiovascular abnormalities. Thus, echocardiograms have been suggested for use in preoperative screening in patients with significant scoliosis. However, the utility of preoperative heart screenings in patients without known or suspected heart problems is not well understood.
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