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Mol Divers
January 2025
School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.
The 2-substituted benzimidazole has emerged as a promising heterocyclic compound in the field of drug design. In pursuit of more sustainable photocatalysts for 2-substituted benzimidazole synthesis, the method for coating FeO with V-doped TiO was presented. On the base of characterizing composition, morphology, and properties, the prepared nano-sized FeO@V/TiO composites were used as a heterogeneous photocatalyst to catalyze the synthesis of 2-substituted benzimidazoles under light.
View Article and Find Full Text PDFChembiochem
January 2025
Southeast University, School of Biological Science and Medical Engineering, 2 Sipailou, Xuanwu District, 210096, Nanjing, CHINA.
In recent years, antimicrobial peptides (AMPs) have emerged as a potent weapon against the growing threat of antibiotic resistance. Among AMPs, the ones containing tryptophan (W) and arginine (R) exhibit enhanced antimicrobial properties, benefiting from the unique physicochemical features of the two amino acids. Herein, we designed three hexapeptides, including WR, DWR (D-isomer), and RF, derived from the original sequence, RWWRWW-NH2 (RW).
View Article and Find Full Text PDFFront Cell Infect Microbiol
January 2025
Mkelly Biotech Pvt Ltd., Mohali, Punjab, India.
Background: The rise of antibiotic-resistant pathogens has intensified the search for novel antimicrobial agents. This study aimed to isolate from local soil samples and evaluate its antimicrobial properties, along with optimizing the production of bioactive compounds.
Methods: Soil samples were collected from local regions, processed, and analysed for Streptomyces strains isolation using morphological characteristics and molecular identification through 16S rRNA gene PCR assay.
RSC Adv
January 2025
Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig Beethovenstr. 55 38106 Braunschweig Germany
The antimicrobial properties of silver and silver complexes have been known in medicine since ancient times. However, limitations in stability and solubility have impaired medicinal chemistry and drug development research. With the advent of N-heterocyclic carbenes (NHC) as ligands, the development of synthesis methods for organometallic silver species of the type (NHC)AgX (where X = halide) has brought significant improvements, and the class of antimicrobial silver NHC complexes has emerged.
View Article and Find Full Text PDFMater Today Bio
February 2025
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstraße 6, 91058, Erlangen, Germany.
In recent years, metal-organic frameworks (MOFs) have emerged as promising materials for biomedical applications, owing to their superior chemical versatility, unique textural properties and enhanced mechanical properties. However, their fast and uncontrolled degradation, together with the reduced bioactivity have restricted their clinical potential. To overcome these limitations, MOFs can be synergistically combined with other materials, such as bioactive glasses (BGs), known for their bioactivity and therapeutic ion releasing capabilities.
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