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Stability of bilirubin and oxyhaemoglobin in cerebrospinal fluid.
Scand J Clin Lab Invest
January 2025
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Cerebrospinal fluid (CSF) is routinely investigated to diagnose subarachnoid haemorrhage (SAH) in cases with unclear neuroimaging findings. Using spectrophotometry, the levels of bilirubin and oxyhaemoglobin are analysed. This study investigates the stability for bilirubin and oxyhaemoglobin in CSF samples for up to 3 weeks measured with a spectrophotometer.
View Article and Find Full Text PDF[Clinical-biological approaches to the spectrophotometric detection of oxyhemoglobin and bilirubin in CSF in the management of aneurysmal subarachnoid hemorrhage].
Ann Biol Clin (Paris)
November 2024
Service de Biochimie et Génétique Moléculaire, CHU Gabriel Montpied, 58 Rue Montalembert, 63000 Clermont-Ferrand, France.
The diagnosis of subarachnoid hemorrhage (SAH) is extremely important for appropriate management. Cerebral computed tomography (CT), used as the first-line investigation to detect bleeding, has excellent sensitivity if performed promptly, but its sensitivity falls sharply with the time elapsed since the onset of SAH. Oxyhemoglobin and bilirubin, the breakdown products of heme, are detectable in cerebrospinal fluid (CSF) by spectrophotometric absorption, which defines the search for xanthochromia pigment in CSF.
View Article and Find Full Text PDFA Method for Compensating Hemoglobin Interference in Total Serum Bilirubin Measurement Using a Simple Two-Wavelength Reflectance Photometer.
Sensors (Basel)
October 2024
Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy.
Neonatal hyperbilirubinemia (NH) is a common condition in newborns, with elevated bilirubin levels potentially causing neurological damage or death. Accurate and timely measurements of total serum bilirubin are essential to prevent these outcomes. Direct spectrophotometry, a reliable method for measuring bilirubin, is particularly useful in constrained settings due to its potential for portable low-cost instrumentation.
View Article and Find Full Text PDFMachine learning assisted rapid approach for quantitative prediction of biochemical parameters of blood serum with FTIR spectroscopy.
Spectrochim Acta A Mol Biomol Spectrosc
February 2025
Institute of Spectroscopy, Russian Academy of Sciences, 108840 Troitsk, Russia; National Research University Higher School of Economics, 101000 Moscow, Russia; Advanced Research Institute of Multidisciplinary, Beijing Institute of Technology, 100081 Beijing, China. Electronic address:
This study develops regression models for predicting blood biochemical data using Fourier-transform infrared spectroscopy (FTIR) analysis. Absorption at specific wavelengths of blood serum is revealed to have strong correlations with biochemical parameters, such as ALT, amylase, AST, protein, bilirubin, Gamma-GT, iron, calcium, uric acid, triglycerides, phosphatase and cholesterol, were shown. The results consistently demonstrate that Random Forest Regression outperforms other models, delivering impressive outcomes for the majority of the analyzed parameters.
View Article and Find Full Text PDFVisual inspection versus spectrophotometry for xanthochromia detection in patients with sudden onset severe headache-A diagnostic accuracy study.
Headache
January 2025
Department of Neurology, Nordland Hospital Trust, Bodø, Norway.
Objective: There is still disagreement about whether to routinely use spectrophotometry to detect xanthochromia in cerebrospinal fluid (CSF) or whether visual inspection is adequate. We aimed to evaluate the diagnostic accuracy of these methods in detecting an aneurysmal subarachnoid hemorrhage in patients with sudden onset severe headache.
Background: When a patient presents to the emergency department with a headache for which there is suspicion of a subarachnoid hemorrhage, the gold standard to rule this out is to perform a CSF analysis for xanthochromia with or without spectrophotometry if the cranial non-contrast computed tomography (CT) upon admission is negative.
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