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The Importance of Early Detection and Prevention of Atypical Skin Lesions and Other Melanoma Risk Factors in a Younger Population.
Cancers (Basel)
December 2024
Department of Dermatology and Venereology, Medical University of Lodz, pl. Hallera 1, 90-647 Lodz, Poland.
Background/objectives: Skin cancer is becoming increasingly common due to increasing risk factors such as excessive ultraviolet (UV) radiation, genetic predisposition, fair skin, and a history of sunburn. Melanoma accounts for only 1% of cases but causes most skin cancer deaths. Dysplastic nevi (DN) are important precursors of melanoma.
View Article and Find Full Text PDFBackground: Skin cancer poses a significant global health threat, with early detection being essential for successful treatment. While deep learning algorithms have greatly enhanced the categorization of skin lesions, the black-box nature of many models limits interpretability, posing challenges for dermatologists.
Methods: To address these limitations, SkinSage XAI utilizes advanced explainable artificial intelligence (XAI) techniques for skin lesion categorization.
SOX-10 and Melan-A Immunostaining in Areas of Focal Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis Within Dysplastic Nevi Biopsies: An Observational Study.
Am J Dermatopathol
January 2025
Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH; and.
Background: Focal acantholytic dyskeratosis (FAD) and epidermolytic hyperkeratosis (EHK) are common incidental epidermal histologic findings within dysplastic nevi biopsies. We evaluate whether areas of FAD and EHK within dysplastic nevi biopsies stain with immunostains used to characterize melanocytic neoplasms.
Methods: In this case series, a natural language search of histopathology reports from our institution in the past year (2020-2021) identified dysplastic nevus biopsies with concurrent FAD and/or EHK.
Dermatoscopic Radial Rippling of Pigment: A Potential Indicator of Pigmented Bowen's Disease.
Skinmed
October 2024
Empire Dermatology (Private Practice), Syracuse, NY.
Article Synopsis
- - Pigmented Bowen's disease (pBD) is a rare form of Bowen's disease, making up only 1.67%-5.5% of lesions, and it can be mistaken for various skin conditions like actinic keratosis and melanoma.
- - This skin condition usually appears as a flat or slightly raised, scaly, and well-defined plaque, mainly affecting individuals in their sixties and is generally asymptomatic.
- - Key risk factors for developing pBD include HPV infection, exposure to arsenic and sunlight, ionizing radiation, and skin trauma.
A genetically informed study reveals modifiable pathways in skin cancer.
J Transl Med
October 2024
Starbody Plastic Surgery Clinic, No. 271 South Hushu Road, Hushu District, Hangzhou, Zhejiang, 310007, China.
Article Synopsis
- This study investigates the causal links between modifiable risk factors and skin cancer using Mendelian randomization, aiming to improve prevention strategies.
- It utilized genetic instruments for 53 different risk factors, performing analyses on three main types of skin cancer: melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC).
- The results confirmed known risk factors and introduced new ones, highlighting a need for further research to understand their biological implications and guide public health initiatives.*
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