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Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.
Reprod Sci
March 2012
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Progesterone plays a critical role in regulating cervical structure necessary for pregnancy maintenance. Preterm labor and early cervical ripening are often associated with localized infection. We hypothesized that proinflammatory cytokines enhance progesterone metabolism in human cervical fibroblasts (HCFs) in vitro, through the regulation of the expression of 20α-hydroxysteroid dehydrogenases (aldo-keto reductase [AKR]1C1, AKR1C2, or AKR1C3), 5α-reductase type 1 (5α-RDT1), and/or 17β-hydroxysteroid dehyrogenases (17β-HSD) type 1 and 2.
View Article and Find Full Text PDF[Hydroxysteroid dehyrogenases, delta 5-3-ketosteroid isomerase and delta 4-steroid hydrogenase in erythrocytes].
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol
November 1998
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