Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen.
Elife
January 2025
Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Trained immunity (TI) is the process wherein innate immune cells gain functional memory upon exposure to specific ligands or pathogens, leading to augmented inflammatory responses and pathogen clearance upon secondary exposure. While the differentiation of hematopoietic stem cells (HSCs) and reprogramming of bone marrow (BM) progenitors are well-established mechanisms underpinning durable TI protection, remodeling of the cellular architecture within the tissue during TI remains underexplored. Here, we study the effects of peritoneal Bacillus Calmette-Guérin (BCG) administration to find TI-mediated protection in the spleen against a subsequent heterologous infection by the Gram-negative pathogen Typhimurium (.
View Article and Find Full Text PDFComparative phytochemical and pharmacological analysis of two cultivars of Annona squamosa L. cultivated in Egypt.
NPJ Sci Food
January 2025
Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Article Synopsis
- The study compared two cultivars of Annona squamosa (Abdelrazik and Balady) in terms of their chemical profiles and cytotoxic effects against cancer cell lines.
- Annona A. showed higher acetogenin content and stronger cytotoxic activity, while Annona B. had more carbohydrates but less magnesium.
- DNA barcoding identified effective methods for species and cultivar differentiation, suggesting that Annona squamosa cultivars might be useful in developing cancer therapies and immune boosters.
Molecular characterization and phylogenetic analysis of African swine fever virus from a pig farm in India.
Vet Res Forum
November 2024
Department of Veterinary Medicine, College of Veterinary and Animal Sciences, Sardar Vallabhbhai Patel University of Agriculture and Technology, Meerut, India.
African swine fever (ASF) is considered as one of the most threatening diseases for the pig farming industry all over the world. Due to the lack of an effective vaccine, organized farms and backyard rearing must strictly enforce control measures in order to combat the disease. The present report describes the ASF epidemic in a piggery in Uttar Pradesh state, India.
View Article and Find Full Text PDFMultiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen.
J Am Chem Soc
January 2025
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Lipid nanoparticles (LNPs) have emerged as pivotal vehicles for messenger RNA (mRNA) delivery to hepatocytes upon systemic administration and to antigen-presenting cells following intramuscular injection. However, achieving systemic mRNA delivery to non-hepatocytes remains challenging without the incorporation of targeting ligands such as antibodies, peptides, or small molecules. Inspired by comb-like polymeric architecture, here we utilized a multiarm-assisted design to construct a library of 270 dendron-like degradable ionizable lipids by altering the structures of amine heads and multiarmed tails for optimal mRNA delivery.
View Article and Find Full Text PDFModulatory action of Bryonia alba on the immune system in cyclophosphamide induced immunosuppression in BALB/c mice.
PLoS One
December 2024
Drug Standardization, Central Council for Research in Homoeopathy, New Delhi, India.
Article Synopsis
- Oxidative stress and inflammation are key issues in immune-compromised diseases and cancer treatments, prompting a study on the immune-boosting effects of Bryonia alba (BA) in mice with induced immune deficiency.
- The research involved treating BALB/c mice with various potencies of BA after cyclophosphamide administration, resulting in significant improvements in immune parameters like RBC and WBC levels, and increased expression of important immune cytokines.
- Histopathology showed that BA-treated mice maintained healthy spleen structures compared to those damaged by cyclophosphamide, suggesting BA's potential as an effective immunostimulant during chemotherapy, but more studies are needed on its effects against immune-compromised infections.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!