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[Evaluation of the toxicity of perfluorooctanoic acid toward human colorectal cancer cells using multi-dimensional approaches].
Se Pu
January 2025
School of Marine Sciences, Sun Yat-sen University, Zhuhai 519082, China.
Article Synopsis
- Human exposure to perfluorooctanoic acid (PFOA) can lead to ulcerative colitis, but the mechanisms of its toxicity in intestinal cells remain unclear.
- Researchers studied the effects of PFOA on human colorectal cancer cells (HCT116) by examining cell viability, mitochondrial activity, and gene expression related to metabolism.
- They found that 300 μmol/L of PFOA significantly reduced the viability of HCT116 cells and altered metabolic gene expression, while lower concentrations (50 μmol/L) increased mitochondrial respiratory activity.
- The study suggests that mitochondrial activity could indicate PFOA's effects, and specific genes could play a role in the development of ulcerative colitis linked to PFOA exposure
Reducing the bitterness of angiotensin-I-converting enzyme (ACE) inhibitory peptides from soybean protein by NADES-driven Maillard reaction.
Food Chem
March 2025
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, Guangzhou 510650, China. Electronic address:
Soybean peptide (SP) exhibits significant angiotensin-I-converting enzyme inhibitory (ACEI) activity, however, its strong bitterness restricts its use in food industry. This study aimed to reduce the bitterness of SP by natural deep eutectic solvent (NADES)-driven Maillard reaction (MR). Results showed that both the mixtures of Glucose-NADES and the Glucose-Xylose-NADES formed the hydrogen bonds and shown good thermal stability analyzed by using Fourier transform infrared (FTIR), Differential scanning calorimetry (DSC) and Thermogravimetric analysis (TGA).
View Article and Find Full Text PDFInvestigation of the Interaction Between Angiotensin-Converting Enzyme (ACE) and ACE-Inhibitory Tripeptide from Casein.
Int J Mol Sci
December 2024
Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Higher Education Institutes Key Laboratory for New Chemical and Biological Transformation Process Technology, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Angiotensin-converting enzyme (ACE) inhibitory peptides exhibit antihypertensive effects by inhibiting ACE activity, and the study of the interaction between ACEs and inhibitory peptides is important for exploring new therapeutic strategies. In this study, the ACE-inhibitory peptide isolated from casein hydrolysate with the amino acid sequence Leu-Leu-Tyr (LLY) exhibited high ACE-inhibitory activity and stability, which holds significant implications for biochemistry and pharmaceutical applications. Furthermore, systematic investigations were conducted on the interaction between ACE and LLY through various approaches.
View Article and Find Full Text PDFCaptopril prevents depressive-like behavior in an animal model of depression by enhancing hippocampal neurogenesis via activation of the ACE2/Ang (1-7)/Mas receptor/AMPK/BDNF pathway.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Article Synopsis
- The brain's Renin-Angiotensin System, particularly through the action of angiotensin (Ang) converting enzyme (ACE) 2 and Ang (1-7), is linked to mood regulation and potential antidepressant effects.
- In a study with olfactory bulbectomized (OBX) mice, the ACE inhibitor Captopril (Cap) was found to reduce depressive-like behaviors in these mice, as it increased levels of Ang (1-7) and other neuroprotective factors in the hippocampus.
- The antidepressant effects of Cap and Ang (1-7) were inhibited when specific receptors were blocked, indicating that these pathways are crucial for the observed mood improvements.
From Sea to Lab: Angiotensin I-Converting Enzyme Inhibition by Marine Peptides-Mechanisms and Applications.
Mar Drugs
September 2024
Department of Food Science and Technology, Pukyong National University, Busan 48513, Republic of Korea.
To reveal potent ACE inhibitors, researchers screen various bioactive peptides from several sources, and more attention has been given to aquatic sources. This review summarizes the recent research achievements on marine peptides with ACE-inhibitory action and application. Marine peptides are considered excellent bioactives due to their large structural diversity and unusual bioactivities.
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