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A 73-year-old man presented with a 2-week history of intermittent right-sided chest pain, cough, and progressive dyspnea on exertion. He reported subjective weight loss and anorexia with early satiety over the preceding months. He denied any fevers, night sweats, or sick contacts.
View Article and Find Full Text PDFOnline monitoring and stable isotope tracing of cancer associated volatiles in murine model captures tumor associated markers in vivo.
Anal Chim Acta
May 2025
Department of Human Sciences, The Ohio State University, USA; James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA. Electronic address:
Background: The imperative need for early cancer detection, which is crucial for improved survival rates in many severe cancers such as lung cancer, remains challenging due to the lack of reliable early-diagnosis technologies and robust biomarkers. To address this gap, innovative screening platforms are essential to unveil the chemical signatures of lung cancer and its treatments. It is established that the oxidative tumor environment induces alterations in host metabolic processes and influences endogenous volatile synthesis.
View Article and Find Full Text PDFIdentifying promising peptide targets for leprosy serological tests: From prediction to ELISA.
J Genet Eng Biotechnol
March 2025
Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Programa de Pós-Graduação em Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:
Leprosy remains a significant health concern, particularly in India, Brazil, and Indonesia. Early diagnosis is essential to prevent complications, highlighting the need for improved diagnostic tools. This study aimed to identify novel Mycobacterium leprae antigens and assess their effectiveness against human sera through immunotools for antibody response evaluation.
View Article and Find Full Text PDFSpousal perceptions and their role in promoting breast cancer screening: a focus group study.
BMJ Open
March 2025
Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore
Objectives: To explore husbands' views on breast cancer screening, risk-based screening and their role in influencing their wives' health-seeking behaviours.
Design: Qualitative focus group discussion (FGD) supplemented by quantitative data from a cohort study using a structured questionnaire.
Setting: This study was conducted in a community-based setting, with participants recruited online through non-profit organisations via social media and email.
Identification of distinct clinical profiles of sepsis risk in paediatric emergency department patients using Bayesian profile regression.
BMJ Paediatr Open
March 2025
Children's Intensive Care Research Program, Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Background: Sepsis affects 25 million children and neonates annually, causing significant mortality and morbidity. Early identification and treatment are crucial for improving outcomes. Identifying children at risk is challenging due to clinical heterogeneity and overlap with other conditions.
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