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Persisting challenges in the development of predictive biomarkers for immuno-oncology therapies for renal cell carcinoma.
Expert Rev Anticancer Ther
January 2025
Department of Urology, Iwate Medical University, Shiwa, Iwate, Japan.
Introduction Immuno-oncology (IO) therapies have become integral to renal cell carcinoma (RCC) management, RCC remains a complex malignancy with diverse clinical behaviors and a heterogeneous tumor microenvironment, highlighting the need for predictive biomarkers to optimize therapy. Areas covered This review synthesizes recent findings from clinical trials, translational studies, and molecular analyses to provide an updated perspective on biomarker research for IO therapies in RCC. A literature search was conducted using PubMed, Embase, and Web of Science for articles published between January 2010 and November 2024.
View Article and Find Full Text PDFAdvances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors.
Front Immunol
January 2025
Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, United States.
Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies, achieving remarkable clinical success with FDA-approved therapies targeting CD19 and BCMA. However, the extension of these successes to solid tumors remains limited due to several intrinsic challenges, including antigen heterogeneity and immunosuppressive tumor microenvironments. In this review, we provide a comprehensive overview of recent advances in CAR T cell therapy aimed at overcoming these obstacles.
View Article and Find Full Text PDFBIMSSA: enhancing cancer prediction with salp swarm optimization and ensemble machine learning approaches.
Front Genet
January 2025
Department of Mechatronics Engineering, Parul Institute of Technology, Parul University, Vadodara, Gujarat, India.
Background: Cancer rates are rising rapidly, causing global mortality. According to the World Health Organization (WHO), 9.9 million people died from cancer in 2020.
View Article and Find Full Text PDFSupervised machine learning and genotype by trait biplot as promising approaches for selection of phytochemically enriched genotypes.
Heliyon
January 2025
Faculty of Engineering, University of Maragheh, Maragheh, Iran.
Sumac is considered as a medicinal and industrial plant. Climate change threats natural ecosystems and hence, evaluation of sumac's genetic diversity, identification of superior genotypes, and conservation of such materials is important. In this study, 5 wild populations of sumac were investigated.
View Article and Find Full Text PDFEvolutionary Genomics of Two Co-occurring Congeneric Fore Reef Coral Species on Guam (Mariana Islands).
Genome Biol Evol
January 2025
Island Evolution Laboratory, Marine Laboratory, University of Guam, Mangilao, GU 96923, USA.
Population structure provides essential information for developing meaningful conservation plans. This is especially important in remote places, such as oceanic islands, where limited population sizes and genetic isolation can make populations more susceptible and self-dependent. In this study, we assess and compare the relatedness, population genetics and molecular ecology of two sympatric Acropora species, A.
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