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Cutaneous signs of systemic disease.
Clin Dermatol
December 2011
UMDNJ-New Jersey Medical School, Newark, NJ, USA.
Article Synopsis
- - Common dermatologic eponyms and skin signs, like Aldrich-Mees' lines and Beau's lines, aid in diagnosing various conditions, ranging from arsenic poisoning to liver disease and systemic lupus erythematosus.
- - Specific signs indicate serious health issues: for example, Gottron's papules relate to dermatomyositis, Janeway's lesions are tied to bacterial endocarditis, and palpable purpura points to leukocytoclastic vasculitis.
- - Certain skin changes, like acanthosis nigricans and Dennie-Morgan folds, can signal internal malignancies or other diseases, highlighting the importance of dermatologic signs in medical diagnostics.
[Will acanthosis nigricans be a new cutaneous manifestation of human immunodeficiency virus infection?].
Acta Med Port
October 1997
Serviço de Medicina I, Hospital Curry Cabral, Lisboa.
The authors describe a clinical case of AIDS presented by three opportunistic infections (esophageal candidiasis, tuberculosis and atypical mycobacteriosis) and a dermatological manifestation--acanthosis nigricans--not described in medical literature as accompanying those entities. The exclusion of most common etiologies of acanthosis nigricans and its regression following treatment for those infections suggests that with AIDS it behaves like a paraneoplastic syndrome. Screening for HIV antibodies should be the rule whenever this dermatological manifestation is present.
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