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Polysaccharides isolated from Cibotium barometz attenuate chronic inflammatory pain: Molecular chemical structure and role of phenylalanine.
Int J Biol Macromol
January 2025
Department of Pain Management, Qilu Hospital of Shandong University, 107# West Wenhua Road, Jinan, Shandong 250012, China. Electronic address:
This investigation represents a pioneering effort to examine the therapeutic effects of PCB specifically in the context of CFA-induced mice, as well as to elucidate the underlying mechanisms that facilitate such effects. Our study utilized advanced methodologies, namely high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS)-based metabolomics, alongside comprehensive multivariate data analysis, to identify a distinctive metabolic profile associated with acute inflammation. Through our analyses, we discovered that several potential metabolites were significantly implicated in a variety of critical metabolic pathways.
View Article and Find Full Text PDFBehind Closed Eyes: Understanding Nightmares in Children and Adolescents with Autism Spectrum Disorder - A Systematic Review.
Neurosci Biobehav Rev
January 2025
Department of Psychology, Sapienza University of Rome, Rome, Italy; Body and Action Lab, IRCCS Fondazione Santa Lucia, Rome, Italy. Electronic address:
Introduction: Brain and sleep development in childhood shapes emotional and cognitive growth, including the ability to recall dreams. In line with the continuity hypothesis of dreaming, several findings suggest a link between clinical symptoms and nightmare frequency. Sleep disorders and anxiety are among the most frequently co-occurring conditions in children and adolescents with autism spectrum disorder (ASD).
View Article and Find Full Text PDFNineteenth-century land use shapes the current occurrence of some plant species, but weakly affects the richness and total composition of Central European grasslands.
Landsc Ecol
January 2025
Department of Spatial Sciences, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Praha - Suchdol, Czech Republic.
Context: Historical land use is thought to have influenced plant community diversity, composition and function through the local persistence of taxa that reflect ecological conditions of the past.
Objectives: We tested for the effects of historical land use on contemporary plant species richness, composition, and ecological preferences in the grassland vegetation of Central Europe.
Methods: We analyzed 6975 vegetation plots sampled between 1946 and 2021 in dry, mesic, and wet grasslands in the borderland between Austria, the Czech Republic, and Slovakia.
PTPMT1 inhibition induces apoptosis and growth arrest of human SCLC cells by disrupting mitochondrial metabolism.
Transl Cancer Res
December 2024
Department of Medical Oncology, Qinghai Provincial People's Hospital, Xining, China.
Background: Many cancer cells exhibit aberrant metabolic reprogramming through abnormal mitochondrial respiration. Protein tyrosine phosphatase mitochondrial 1 (PTPMT1) is a protein tyrosine phosphatase localized to the mitochondria and linked to mitochondrial respiration. However, the expression and role of PTPMT1 in regulating the biological characteristics of small cell lung cancer (SCLC) has not yet been explored.
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