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Evaluating pathological complete response as an surrogate endpoint for long-term survival in patients with non-small cell lung cancer: a systematic review and meta-analysis.
Int J Surg
December 2024
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Purpose: Pathologic complete response (pCR) is deemed to associate with event-free survival (EFS) and overall survival (OS), however,whether it is suitable to serve as a surrogate endpoint for long-term survival in clinical trials of neo-adjuvant treatment for resectable NSCLC trials is still controversy. We aim to evaluate the role of pCR and its viability as a surrogate endpoint for EFS and OS in NSCLC.
Unlabelled: Methods.
The glycogene alterations and potential effects in esophageal squamous cell carcinoma.
Cell Mol Life Sci
December 2024
Department of Pathology, Basic Medical Sciences Center, Key Laboratory of Cellular Physiology of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Article Synopsis
- Aberrant glycosylation is a key feature of cancer, but the specific glycogenes involved in esophageal squamous cell carcinoma (ESCC) remain largely unidentified, prompting this research.
- The study utilized various methods, including genomic analysis and experiments on cell proliferation and metastasis, to evaluate the impact of the glycogenes POFUT1 and RPN1 in ESCC.
- Results showed that increased expression of POFUT1 and RPN1 correlates with worse patient outcomes and enhanced cancer progression, with POFUT1 influencing migration through the Notch signaling pathway, suggesting both glycogenes as potential targets for cancer treatment in ESCC.
Axillary-coronary artery bypass using a vein graft via the suprasternal route.
Asian Cardiovasc Thorac Ann
November 2024
Department of Cardiac Surgery, Asahikawa Medical University, Asahikawa, Japan.
Redo coronary artery bypass grafting after an right internal thoracic artery graft to the left anterior descending artery is challenging. For such a 52-year-old male patient with a history of mediastinitis, we performed redo bypass grafting of the right coronary artery using a saphenous vein graft and xiphoid resection via the suprasternal route with the left axillary artery as the inflow source and the graft were patent. The axillary artery is an inflow source for patients with inaccessible aorta.
View Article and Find Full Text PDFSurgery alone versus neoadjuvant chemoradiotherapy followed by surgery in patients with stage T2N0M0 esophageal cancer.
Sci Rep
November 2024
Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Qingxiu District, Nanning, 530021, Guangxi, China.
To compare the survival outcomes of patients with stage T2N0M0 esophageal cancer treated with surgery alone versus those treated with neoadjuvant chemoradiotherapy followed by surgery. Patients with stage T2N0M0 esophageal cancer, who either underwent surgery alone or received neoadjuvant chemoradiotherapy followed by surgery, were extracted from the Surveillance, Epidemiology, and End Results database covering the period from 2000 to 2020. Cancer-specific survival (CSS) and overall survival (OS) between the two treatment groups were compared.
View Article and Find Full Text PDFBurden of In-Hospital Admissions and Outcomes of Thoracic Outlet Compression Syndrome in the United States From 2010 to 2021.
Cureus
October 2024
Internal Medicine, College of Medicine, Imo State University, Owerri, NGA.
Introduction Despite advancements in medical and surgical management, thoracic outlet syndrome (TOS) remains a complex and often understudied condition with variable outcomes. This study assessed hospitalization rates and outcomes, including patient characteristics, mortality risks, and healthcare costs associated with TOS hospitalizations. Methods We analyzed elective and nonelective hospitalization data for TOS between 2010 and 2021 from the National Inpatient Sample (NIS) and National Readmission Databases (NEDS) and classified the data into neurogenic, venous, and arterial subtypes using the International Classification of Diseases (ICD) diagnostic and procedural codes.
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