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Background: The home environment is where daily activities are performed and older adults with and without cognitive impairment spend most of their time. While home safety is a priority for healthcare providers, there is limited understanding of housing characteristics of older adults with cognitive impairment in the United States and whether they differ for those who live alone or with others.
Methods: We draw on data collected from N = 968 community-living older adults with cognitive impairment who responded to the 2022 National Health and Aging Trends Study, a population-based national survey that comprehensively assesses characteristics of older adults (≥65 years) and their households in a two-hour in-home interview.
Biological Amyloids Chemically Damage DNA.
ACS Chem Neurosci
January 2025
Department of Life Sciences, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Amyloid fibrils are protein polymers noncovalently assembled through β-strands arranged in a cross-β structure. Biological amyloids were considered chemically inert until we and others recently demonstrated their ability to catalyze chemical reactions in vitro. To further explore the functional repertoire of amyloids, we here probe if fibrils of α-synuclein (αS) display chemical reactivity toward DNA.
View Article and Find Full Text PDFAdvancing plant science through precision 3D bioprinting: new tools for research and biotech applications.
Curr Opin Biotechnol
January 2025
Department of Plant and Microbial Biology and NC Plant Sciences Initiative, North Carolina State University, Raleigh, NC 27695, USA. Electronic address:
The integration of 3D bioprinting into plant science and biotechnology is revolutionizing research and applications. While many high-throughput techniques have advanced plant biology, replicating the complex 3D organization and cellular environments of plant tissues remains a significant challenge. Traditional 2D culture systems fall short of capturing the necessary spatial context for accurate studies of cell behavior, gene expression, and tissue development.
View Article and Find Full Text PDFOrderly Arranged Cubic Quantum Dots along Supramolecular Templates of Naphthalenediimide Aggregates.
Angew Chem Int Ed Engl
January 2025
Kyoto University: Kyoto Daigaku, Institute for Chemical Research, JAPAN.
Precise control of assembled structures of quantum dots (QDs) is crucial for realizing the desired photophysical properties, but this remains challenging. Especially, the one-dimensional (1D) control is rare due to the nearly isotropic nature of QDs. Herein, we propose a novel strategy for controlling the 1D-arrangement range of cubic perovskite QDs in solution based on the morphological modification of a supramolecular polymer (SP) template.
View Article and Find Full Text PDFEffect of digital health applications with or without gamification on physical activity and cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials.
EClinicalMedicine
October 2024
Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.
Background: Use of health applications (apps) to support healthy lifestyles has intensified. Different app features may support effectiveness, including gamification defined as the use of game elements in a non-game situation. Whether health apps with gamification can impact behaviour change and cardiometabolic risk factors remains unknown.
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