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[Recommendations for clinical practice: Prevention and management of varicella zoster virus (VZV) infection during pregnancy and the perinatal period (extended version)].
Gynecol Obstet Fertil Senol
January 2025
Division of Virology, WHO Rubella National Reference Laboratory, Paris Saclay University Hospital, APHP, Paris, France; Université Paris-Saclay, INSERM U1184, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses, France.
The Société de Pathologie Infectieuse de Langue Française released in 2024 a new national recommendation for clinical practice on the prevention and management of varicella zoster virus (VZV) infection during pregnancy and the perinatal period. The previous recommendation was issued in 1998, at a time of anti-VZV immunoglobulins shortage; it has hence become obsolete. This recommendation is a formalized expert consensus focusing on infectious diseases management; it is drawn up by a multidisciplinary working group (infectiologists, obstetricians, pediatricians, microbiologists, midwives, hygienists).
View Article and Find Full Text PDFProteomic profiling of neonatal herpes simplex virus infection on dried blood spots.
Commun Med (Lond)
December 2024
Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Background: Neonatal herpes simplex virus (HSV) infection is life-threatening, with a mortality of up to 70-80% when disseminated, often due to vague symptoms and delayed treatment. Neonatal screening using dried blood spot (DBS) samples is among the most impactful preventative health measures ever implemented, but screening for HSV has not been investigated.
Methods: We investigated high throughput multiplexed proteomics on DBS samples collected on days 2-3 of life from a nationwide cohort of neonates with HSV infection (n = 53) and matched controls.
Viral Polymerase Chain Reaction Testing of the Cerebrospinal Fluid: Comprehensive Care for Neonates With a Fever.
Cureus
October 2024
Neonatology, Jersey Shore University Medical Center, Neptune, USA.
Neonates who develop fever have a high risk for serious infection, and while the standard of care involves performing a full sepsis evaluation, current guidelines do not include viral polymerase chain reaction (PCR) testing of the cerebrospinal fluid as a standard of care, which means that cases of viral meningitis can be missed. This case presentation discusses a neonate who had a fever at four days of life who then underwent a full sepsis evaluation. A respiratory viral panel demonstrated rhino/enterovirus positivity.
View Article and Find Full Text PDF[Genetic diseases with skin fragility in children].
Dermatologie (Heidelb)
December 2024
Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.
Article Synopsis
- Genetic diseases that cause skin fragility are diverse in their symptoms and genetic causes, making it crucial for healthcare professionals to differentiate them from more common conditions like infections or burns.
- The classification of these rare diseases is guided by their clinical presentation, histological characteristics, and genetic mutations, with most treatments being symptomatic rather than curative.
- Advances in genetic testing have integrated the study of these rare diseases into everyday clinical practice, emphasizing the need for collaboration among specialists to ensure proper diagnosis and care for affected children.
Congenital and Perinatal Viral Infections: Consequences for the Mother and Fetus.
Viruses
October 2024
Feto Maternal Centre, Al Markhiya Doha, Doha P.O. Box 34181, Qatar.
Viruses are the most common congenital infections in humans and an important cause of foetal malformations, neonatal morbidity, and mortality. The effects of these infections, which are transmitted in utero (transplacentally), during childbirth or in the puerperium depend on the timing of the infections. These vary from miscarriages (usually with infections in very early pregnancy), congenital malformations (when the infections occur during organogenesis) and morbidity (with infections occurring late in pregnancy, during childbirth or after delivery).
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