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The article analyzes, for the reason of archive and literary sources, the historic medical characteristics of formation of sanitary antiepidemic organization of Yekaterinoslav gubernia. The historic stages are established and the essence and basic principles of formation of preventive direction oa Zemstvo medicine are revealed. It is demonstrated that the achievements of sanitary organization of Yekaterinoslav Zemstvo became possible due to the efforts of progressive Zemstvo sanutary physicians who developed a comprehensive system of sanitary epidemiologic service, the most advanced in Ukraine.

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