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Importance: Hypertension is the primary cardiovascular risk factor in Africa. Recently revised World Health Organization guidelines recommend starting antihypertensive dual therapy; clinical efficacy and tolerability of low-dose triple combination remain unclear.

Objectives: To compare the effect of 3 treatment strategies on blood pressure control among persons with untreated hypertension in Africa.

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Article Synopsis
  • The study investigated the effects of ACE inhibitors and diuretics on heart damage from ischemia-reperfusion in hypertensive rats, showing significant blood pressure reduction and improved heart function.
  • After four weeks of treatment, a combination of drugs decreased left ventricular hypertrophy and increased ejection fraction, but also indicated potential pro-oxidative effects.
  • Pathological analysis revealed no significant changes in heart and kidney tissues, and further research is necessary to explore the long-term effects of these medications.
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Gitelman syndrome with diabetes and kidney stones: A case report.

Medicine (Baltimore)

January 2025

The Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou, China.

Rationale: Gitelman syndrome (GS) is a rare hereditary electrolyte disorder caused by mutations in the SLC12A3 gene. There is limited literature on the role of hydrochlorothiazide (HCT) testing and the SLC12A3 single heterozygous mutation in the diagnosis and management of patients with GS. In addition, cases of GS with concomitant kidney stones are rare.

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A low-cost and renewable magnetite-pine bark (MPB) sorbent was evaluated in continuous-flow systems for the removal of various pharmaceuticals from municipal wastewater effluent following membrane bioreactor (MBR) treatment. A 33-day small-scale column test (bed volume: 791 cm) was conducted using duplicate columns of biochar (BC, Novocarbo) and activated carbon (AC, ColorSorb) as reference for two columns of BC and MPB in order to compare the efficiency of AC and MPB. After the small-scale column test, the pharmaceutical concentrations were generally below the detection limit.

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A Challenging Case of Recurrent Ogilvie Syndrome: Exploring Causes and Treatment Modalities.

Case Rep Gastrointest Med

December 2024

Department of Cardiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Acute colonic pseudo-obstruction (ACPO), or Ogilvie syndrome, is a rare condition marked by significant colon distention without mechanical obstruction. Symptoms include abdominal pain, bloating, nausea, vomiting, and an inability to pass gas or stool. Although common in males over 60, we report a challenging case of a 44-year-old man from Africa with recurrent abdominal distention and discomfort.

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