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Human motivation is organized hierarchically, from proximal (means) to ultimate (ends).
Behav Brain Sci
January 2025
Département d'études cognitives, Institut Jean Nicod, Ecole normale supérieure, Université PSL, EHESS, CNRS, Paris,
Murayama and Jach raise a key problem in behavioral sciences, to which we suggest evolutionary science can provide a solution. We emphasize the role of adaptive mechanisms in shaping behavior and argue for the integration of hierarchical theories of goal-directed cognition and behavioral flexibility, in order to unravel the motivations behind actions that, in themselves, seem disconnected from adaptive goals.
View Article and Find Full Text PDFMetal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant -Induced Osteomyelitis.
ACS Nano
January 2025
Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Methicillin-resistant (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn and vancomycin (Van) codelivered nanotherapeutic (named Man-Zn/Van NPs) was fabricated and characterized via mannose (Man) modification. Man-Zn/Van NPs exhibit significant inhibitory activity against extra- and intracellular MRSA and obviously decrease the minimum inhibitory concentration of Van.
View Article and Find Full Text PDFTraumatic limb amputations in polytrauma ICU admissions.
S Afr J Surg
December 2024
Department of Surgical Sciences, Nelson R Mandela School of Clinical Medicine, University of KwaZulu-Natal, South Africa.
Background: KwaZulu-Natal bears a significant trauma burden, with polytrauma patients often experiencing traumatic limb amputations. This study investigates traumatic limb amputations in the subgroup of severely injured polytrauma patients admitted to the trauma ICU in KwaZulu-Natal. This study aims to describe the management and outcomes of traumatic limb amputations in polytrauma patients at the trauma ICU.
View Article and Find Full Text PDFPreservation of Vascular Endothelial Function in Late-Onset Postmenopausal Women.
Circ Res
January 2025
Department of Integrative Physiology, University of Colorado Boulder (S.D., K.O.M., K.R.L., K.H.A., D.H.C., K.A.F., D.R.S., M.J.R.).
Background: Postmenopausal women (PMW) who complete menopause at a late age (55+ years) have lower cardiovascular disease risk than PMW who complete menopause at a normal age (45-54 years). However, the influence of late-onset menopause on vascular endothelial dysfunction is unknown. Moreover, the mechanisms by which a later age at menopause may modulate endothelial function remain to be determined.
View Article and Find Full Text PDFTheoretical Investigations on the n-Type and p-Type Conductivity Mechanisms in BiTaO Photocatalysts through Intrinsic Point Defects and Group IIA and Group VIB Element Doping.
Inorg Chem
January 2025
Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Education University, Guiyang 550018, China.
The n-type and p-type conductivity mechanisms from intrinsic defects and Group IIA and Group VIB element doping in the photocatalyst BiTaO are systematically investigated by employing hybrid density functional calculations. The results reveal that vacancies , , , and antisite Ta are the predominant defects, depending on growth conditions. Bi-rich, appropriate Ta-rich, and O-poor conditions can promote BiTaO to form n-type conductivity due to the presence of the Ta donor defect and its easier ionization.
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