Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Biomimetic polydopamine loaded with janus kinase inhibitor for synergistic vitiligo therapy via hydrogel microneedles.
J Nanobiotechnology
January 2025
Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Background: Both oxidative stress and autoimmune responses play crucial roles in the development of vitiligo. Under oxidative stress, the apoptotic melanocytes expose self-antigens and release high mobility group box 1 (HMGB1), triggering autoimmune activation and recruiting CD8 T cells. This process further leads to the destruction of melanocytes, resulting in the lack of melanin granules.
View Article and Find Full Text PDFCytotoxicity and genotoxicity of orthodontic bands after aging: an in-vitro study.
BMC Oral Health
January 2025
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, P.O. Box 71345-3119, Shiraz, Iran.
Background: This investigation sought to evaluate cytotoxic and genotoxic effects of two different types of orthodontic bands after aging in acidic and neutral artificial saliva using human gingival fibroblast-like (HGF1-PI 1) cell lines.
Methods: Two commercial brands of orthodontic molar bands (American orthodontic (AO) and 3 S-dental bands), commonly used by orthodontists, were tested. These bands were divided into four groups to examine the effects of aging following thermocycling, and pH variations (pH = 4.
EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction.
Nat Commun
January 2025
Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China.
Myelomatous bone disease is a complication characterized by lytic bone lesions, reduced bone formation, bone pain, and increased fracture risk. Understanding these underlying mechanisms is crucial for developing effective therapeutic approaches. Here we show the role of enhancer of zeste homolog 2 (EZH2) in bone lesions induced by myeloma cells.
View Article and Find Full Text PDFAn agar hydrogel-CuNPs/N@CQDs dual-mode colorimetric/fluorescent indicator for non-destructive monitoring of banana ripening.
Food Chem
January 2025
Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address:
A colorimetric-fluorescence ripeness indicator, based on copper nanoparticles and carbon quantum dots doped with nitrogen (CuNPs/N@CQD) immobilized in agar hydrogel (AGH-CuNPs/N@CQDs) for ethylene gas detection, was developed for detecting the ripening of bananas. Ethylene could reduce the fluorescence intensity of CuNPs/N@CQDs and cause a red shift of the LSPR peak. The prepared AGH-CuNPs/N@CQDs indicator had an irreversible response to ethylene with LOD and LOQ of 9.
View Article and Find Full Text PDF3D examination reveals increased destruction of alpha-actin-positive structures in advanced follicular lymphoma stages.
Acta Histochem
January 2025
Department of Molecular Bioinformatics, Institute of Computer Science, Johann Wolfgang, Goethe-University, Frankfurt/Main, Hessen, Germany; Institut für Allgemeine Pharmakologie und Toxikologie, Goethe University Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany.
Follicular lymphoma (FL) represents the most prevalent subtype of non-Hodgkin's-lymphoma in Western Europe and the United States. While the examination of two-dimensional histological slides remains the gold standard method for diagnosing FL stages, three-dimensional analysis provides additional insights, particularly regarding cellular morphology, spatial relationships and network connectivity. This investigation assessed the tumor-related morphological destruction of fibroreticular cell (FRC) networks bordering germinal centres in FL.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!