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Bone Mineral Density Improvement After Resolution of Endogenous Cushing Syndrome: A Systematic Review and Meta-Analysis.
Endocr Pract
December 2024
Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts.
Objective: We aimed to identify all evidence to evaluate bone mineral density (BMD) improvement after resolution of endogenous Cushing syndrome (eCS).
Methods: Potentially eligible studies were identified from the EMBASE and PubMed databases from inception to February 2024, utilizing a search strategy incorporating terms related to "Bone mineral density" and "Cushing syndrome". Eligible studies must include patients diagnosed with eCS.
Autophagy-dependent hepatocyte secretion of DBI/ACBP induced by glucocorticoids determines the pathogenesis of cushing syndrome.
Autophagy
December 2024
Metabolomics and Cell Biology Platforms, UMS AMMICa, Gustave Roussy Institut, Villejuif, France.
DBI/ACBP is a phylogenetically ancient hormone that stimulates appetite and lipo-anabolism. In response to starvation, DBI/ACBP is secreted through a noncanonical, macroautophagy/autophagy-dependent pathway. The physiological hunger reflex involves starvation-induced secretion of DBI/ACBP from multiple cell types.
View Article and Find Full Text PDFFugitive Acromegaly: A Historical, Clinical, and Translational Perspective.
Front Horm Res
November 2024
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center - Tufts University School of Medicine, Boston, Massachusetts, USA.
The term 'fugitive acromegaly' was introduced by the neurosurgeons Bailey and Cushing in 1928 to describe subjects manifesting signs and symptoms of somatotroph hyperfunction with pituitary insufficiency. Currently, it identifies patients with subtle acromegalic dysmorphisms and inconsistent hormonal profile, possibly presenting only with hyperprolactinemia and related clinical symptoms. Patients have rapidly growing, locally invasive, relapsing pituitary macrotumors that can be classified as either acidophil stem cell tumors (ASCTs) or sparsely granulated somatotroph tumors (SGSTs), both of PIT1-lineage.
View Article and Find Full Text PDFDisease Activity and Bone Microarchitectural Phenotype in Patients With Axial Spondyloarthritis.
HSS J
July 2024
Division of Endocrinology, Department of Medicine, Hospital for Special Surgery, New York City, NY, USA.
Background: Axial spondyloarthritis (AxSpA) is a chronic rheumatic disease characterized by spine inflammation, abnormal bone growth, and paradoxically osteoporosis and vertebral fractures. The pathogenesis of skeletal deficits in this disease is poorly understood.
Purpose: We sought to evaluate volumetric bone mineral density (vBMD) and bone microarchitecture in patients with AxSpA and to identify disease-related factors associated with skeletal abnormalities.
Bone Material Strength index is low in Patients with Cushing's Syndrome even after long-term remission.
J Clin Endocrinol Metab
November 2024
Center for Bone Quality, Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Article Synopsis
- HyperCortisolism in Cushing's syndrome (CS) leads to lower bone mineral density (BMD) and increased fracture risk, with patients experiencing improved BMD post-remission but still having a higher fracture rate.* -
- A study involving 60 patients in remission and 60 matched controls found that despite similar BMD, the bone material strength index (BMSi) was significantly lower in patients, indicating poorer bone quality.* -
- These altered bone properties in CS patients may contribute to ongoing bone fragility, highlighting that BMD alone may not fully assess fracture risk in this group.*
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