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Ossifying fibromyxoid tumours with lipomatous and cartilaginous differentiation: A diagnostic pitfall.
Histopathology
December 2024
Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Aims: Ossifying fibromyxoid tumour is a rare mesenchymal neoplasm predominantly affecting adults characterised by a multinodular growth pattern and the presence of a fibrous pseudocapsule with areas of ossification. Prompted by the recognition of a non-ossifying ossifying fibromyxoid tumour with lipomatous differentiation which caused diagnostic difficulty, we sought to further explore cases of ossifying fibromyxoid tumour with non-osseous heterologous elements.
Methods And Results: A search of our institutional and consultation archives revealed three additional cases that demonstrated lipomatous components and two cases with cartilaginous differentiation.
Primary intracranial dedifferentiated liposarcoma: An extremely rare site with unusual histopathological findings.
Neuropathology
November 2024
Consultant histopathologist, Department of Pathology, Agilus Diagnostics Ltd, Fortis Memorial Research Institute, Gurugram, India.
Primary intracranial sarcomas constitute a rare group of tumors, with the most common types described in the literature being chondrosarcoma and fibrosarcoma. Dedifferentiated liposarcoma (DDLS) is a high-grade sarcoma that sometimes metastasizes to the brain. However, a primary intracranial DDLS is exceedingly rare.
View Article and Find Full Text PDFPseudolipoblastic Perineuroma: A Rare Histologi̇c Subtype.
Am J Dermatopathol
December 2024
U.O.C. Dermatologia, IRCCS Azienda Ospedaliero-Universitaria di Bologna Italia, Bologna, Italy ; and.
Pseudolipoblastic perineurioma is a very uncommon variant of extraneural perineurioma, with only a limited number of cases documented in the medical literature. The most remarkable histopathologic characteristic is the existence of vacuolated cells that closely resemble lipoblasts; besides the presence of small, spindle shaped, or epithelioid perineurial cells. In this study, we present another case of pseudolipoblastic perineurioma, predominantly characterized by the presence of vacuolated "pseudolipoblastic" cells.
View Article and Find Full Text PDFAtypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update.
Cancers (Basel)
September 2024
Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Article Synopsis
- Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare fat tumor that usually appears in the skin layer of middle-aged adults' limbs, potentially returning after incomplete removal but not spreading to distant areas.
- Histologically resembling spindle cell/pleomorphic lipoma, ASCPLT shows a mix of abnormal cells, including atypical spindle cells and multinucleated giant cells, and can sometimes undergo a change to a more aggressive form, although its significance is still unclear.
- The primary treatment is complete surgical removal, and the review covers the tumor's clinical features, pathology, and ongoing discussions about differentiating it from similar tumors.
Pleomorphic Liposarcoma Cytologically Detected in Hemosiderotic Pleural Effusion: Pitfalls Mitigated by Cytologic Clues and Cellblock Immunocytochemistry.
Diagn Cytopathol
December 2024
Cytology Unit, Dubai Hospital, Dubai, UAE.
Article Synopsis
- Sarcomatous serous effusions are rare and difficult to diagnose, especially cases involving dedifferentiated and pleomorphic liposarcomas that can mimic other tumors like carcinoma and mesothelioma.
- A case study describes a 56-year-old man with a large pleural effusion, where cytological analysis revealed highly abnormal tumor cells mixed with macrophages and other components, complicating diagnosis.
- Ultimately, a tissue biopsy confirmed the cytologic diagnosis of pleomorphic liposarcoma, highlighting the importance of detailed cytologic evaluation and the utility of cellblock techniques combined with immunocytochemical analysis.
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