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A pilot human study using ketamine to treat disorders of consciousness.
iScience
January 2025
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Post-comatose disorders of consciousness (DoC) represent persistent neurological conditions with limited therapeutic options and a poor prognosis. Recent works advocate for exploring the effects of psychedelics to enhance brain complexity in DoC and ameliorate their consciousness. We investigated sub-anesthetic concentration of the atypical psychedelic ketamine for treating post-comatose prolonged DoC through a double-blind, placebo-controlled, cross-over trial involving three adult patients.
View Article and Find Full Text PDFWhat is the pathophysiology of inflammation-induced cortical injury in the perinatal brain?
Neural Regen Res
January 2025
The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
Perinatal exposure to infection/inflammation is highly associated with neural injury, and subsequent impaired cortical growth, disturbances in neuronal connectivity, and impaired neurodevelopment. However, our understanding of the pathophysiological substrate underpinning these changes in brain structure and function is limited. The objective of this review is to summarize the growing evidence from animal trials and human cohort studies that suggest exposure to infection/ inflammation during the perinatal period promotes regional impairments in neuronal maturation and function, including loss of high-frequency electroencephalographic activity, and reduced growth and arborization of cortical dendrites and dendritic spines resulting in reduced cortical volume.
View Article and Find Full Text PDFFew-shot transfer learning for individualized braking intent detection on neuromorphic hardware.
J Neural Eng
January 2025
Mechanical and Aerospace, Missouri University of Science and Technology, 400 W 13th St., Rolla, Missouri, 65409, UNITED STATES.
This work explores use of a few-shot transfer learning method to train and implement a convolutional spiking neural network (CSNN) on a BrainChip Akida AKD1000 neuromorphic system-on-chip for developing individual-level, instead of traditionally used group-level, models using electroencephalographic data. The efficacy of the method is studied on an advanced driver assist system related task of predicting braking intention. \emph{Approach}: Data are collected from participants operating an NVIDIA JetBot on a testbed simulating urban streets for three different scenarios.
View Article and Find Full Text PDFStudy Protocol for 'PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity'.
Cureus
January 2025
Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, GBR.
Background: Obsessive-compulsive disorder (OCD) is a complex condition marked by persistent distressing thoughts and repetitive behaviours. Despite its prevalence, the mechanisms behind OCD remain elusive, and current treatments are limited. This protocol outlines an investigative study for individuals with OCD, exploring the potential of psilocybin to improve key components of cognition implicated in the disorder.
View Article and Find Full Text PDFElectroencephalogram biomarkers as predictors of mortality and functional recovery in patients with severe traumatic brain injury: Protocol study.
MethodsX
June 2025
Neurorehabilitation and Neuromodulation Laboratory, Department of Physiological Sciences, Federal University of Espírito Santo, City of Vitória, ES, Brazil.
Traumatic brain injury (TBI) is a global public health condition that causes cognitive and behavioral deficits. This protocol assesses the potential of quantitative electroencephalogram (EEG) biomarkers, associated with inflammatory indicators, to predict mortality and functional recovery in patients with severe TBI. Through continuous monitoring and analysis of abnormal brain activity patterns, the protocol aims to personalize therapeutic interventions and improve patient quality of life.
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