Treatment of an avirulent strain of Trichomonas gallinae with a cellfree homogenate of a virulent strain resulted in enhanced virulence as evidenced by the size of lesions produced in mice. Addition of deoxyribonuclease to the homogenate cell mixture blocked the transformation.
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http://dx.doi.org/10.1126/science.131.3397.352 | DOI Listing |
Appl Environ Microbiol
January 2025
Department of Microbiology & Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
is an opportunistic pathogen with four subspecies: (FNN), (FNV), (FNP), and (FNA), each with distinct disease potentials. Research on fusobacterial pathogenesis has mainly focused on the model strain ATCC 23726 from FNN. However, this narrow focus may overlook significant behaviors of other FNN strains and those from other subspecies, given the genetic and phenotypic diversity within .
View Article and Find Full Text PDFJ Fungi (Basel)
January 2025
School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Since the domestication of plants, pathogenic fungi have consistently threatened crop production, evolving genetically to develop increased virulence under various selection pressures. Understanding their evolutionary trends is crucial for predicting and designing control measures against future disease outbreaks. This paper reviews the evolution of fungal pathogens from natural habitats to agricultural settings, focusing on eight significant phytopathogens: , , spp.
View Article and Find Full Text PDFJ Fungi (Basel)
December 2024
College of Plant Sciences, Jilin University, Changchun 130062, China.
, the grey mould fungus affecting over 1400 plant species, employs infection cushion (IC), a branched and claw-like structure formed by mycelia, as a critical strategy to breach host surface barriers. However, the molecular mechanisms underlying IC formation remain largely unexplored. In this study, we utilized a forward genetics approach to establish a large T-DNA tagged population of , which contained 14,000 transformants.
View Article and Find Full Text PDFHeliyon
January 2025
ANSES - Université de Lyon, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France.
causes hospital-acquired infections in human patients with compromised immune system. Strains associated to nosocomial infections are often resistant to carbapenems and belong to few international clones (IC1-11). .
View Article and Find Full Text PDFUnlabelled: is an emergent fungal pathogen of significant interest for molecular research because of its unique nosocomial persistence, high stress tolerance and common multidrug resistance. To investigate the molecular mechanisms of these or other phenotypes, a handful of CRISPR-Cas9 based allele editing tools have been optimized for . Nonetheless, allele editing in this species remains a significant challenge, and different systems have different advantages and disadvantages.
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