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RNA interference in protozoan parasites and its application.
J Microbiol Immunol Infect
January 2025
Department of Urology, Tungs' Taichung Metro Harbor Hospital, Taichung, Taiwan. Electronic address:
RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression, via small RNA triggers derived from double-stranded RNA that can target specific genes; it is a natural process that plays a role in both the regulation of protein synthesis and in immunity. Discovery of RNAi by Fire and Mello in 1998 had a profound impact on unraveling novel aspects of eukaryotic biology. RNA interference (RNAi) has proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms.
View Article and Find Full Text PDFMolecular prevalence of Giardia duodenalis in domestic pig (Sus domesticus) and captive wild boar (Sus scrofa) in China: A systematic review and meta-analysis.
Vet Parasitol Reg Stud Reports
January 2025
College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China. Electronic address:
Giardia duodenalis is a typical enteric protozoan pathogen that causes diarrhea in humans and various animals, including domestic pigs (Sus domesticus) and wild boars (Sus scrofa). A healthy livestock would help maintain a hygienic environment, which is crucial for human health. This review has summarized the molecular prevalence of G.
View Article and Find Full Text PDFChronic intestinal spirochaetosis and Giardia lamblia infection mimicking eosinophilic enterocolitis.
Lancet Infect Dis
January 2025
Institute of Pathology, University of Brescia-ASST Spedali Civili, Brescia, Italy.
Human intestinal spirochaetosis is caused by the colonisation of the luminal membrane of the colon and rectum by anaerobic spirochaetes belonging to the genus Brachyspira. The common method used for its diagnosis is routine haematoxylin and eosin staining of colonic and rectal biopsy samples. The clinical spectrum of human intestinal spirochaetosis is heterogeneous, ranging from asymptomatic colonisation to symptoms such as chronic mucosal diarrhoea, rectal bleeding, and abdominal pain.
View Article and Find Full Text PDFRhanterium Epapposum Essential Oil and Its Primary Compounds Control Infection, Inflammation, and Serum Electrolyte Imbalance in Mice with Giardiasis.
Acta Parasitol
January 2025
Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, Ad Dawadimi, Shaqra, 17464, Saudi Arabia.
Purpose: The present experimental study seeks to evaluate the in vitro and in vivo effects, as well as the potential mechanisms of action, of Rhanterium epapposum essential oil (REE) and its main constituents against Giardia lamblia infection.
Methods: The analysis of REE was performed using the Gas Chromatography-Mass Spectrometry (GC-MS) detector. The in vitro effects of REE and its main constituents on viability of G.
Molecular Survey of Protist Enteroparasites in Bats (Order Chiroptera) from Portugal.
Acta Parasitol
January 2025
ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Purpose: Bats constitute 20% of all mammal species, playing a vital role in ecosystem health as pollinators, seed dispersers, and regulators of insect populations. However, these animals can also be reservoirs for infectious agents, including viruses, bacteria, and enteroparasites such as Cryptosporidium spp., Giardia duodenalis, and Balantioides coli, raising questions about their role in the epidemiology of these agents.
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