Because a balance between the vasodilator effect of Prostacyclin and the vasoconstrictor effect of Prostaglandin F2 alpha (PGF2 alpha) may be necessary for the regulation of utero-placental-fetal blood flow, a study was designed to assess the influence of a stable prostacyclin analogue, Cicaprost, on the response to Prostaglandin F2 alpha in the perfused human placenta. Cicaprost produced a dose-dependent inhibition of the pressor response of 50 mcg of PGF2 alpha. The decrease in PGF2 alpha-induced pressor response by 0.1 mcg of Cicaprost was not significant, only 6.95 +/- 8.2%. However, 0.5 mcg and 1.0 mcg of Cicaprost significantly attenuated the pressor response of PGF2 alpha by 36.6 +/- 9.5% and 46.8 +/- 8.3%, respectively (MEAN +/- S.E.).
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