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Placental ischemia during pregnancy induces hypertension, cerebral inflammation, and oxidative stress in dams postpartum.
Hypertens Pregnancy
December 2025
Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Background: Preeclampsia (PE) is characterized as de novo hypertension (HTN) with end-organ damage, especially in the brain. PE is hypothesized to be caused by placental ischemia. PE affects ~5-8% of USA pregnancies and increases the risk for HTN and cerebrovascular diseases (CVD) later in life.
View Article and Find Full Text PDFC3AR1 as a target for preeclampsia: from bioinformatics and network pharmacology to experimental validation.
BMC Pregnancy Childbirth
January 2025
Obstetrics and Gynecology Center, Department of Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China.
Background: Preeclampsia, characterized by hypertension and proteinuria during pregnancy, poses significant risks to both mother and fetus. The complement system's aberrant activation, notably the C3AR1, is important to the pathogenesis of preeclampsia, although the precise mechanisms are not fully understood.
Materials And Methods: Utilizing the Comparative Toxicogenomics Database (CTD) and Molecular Signatures Database (MSigDB), we identified complement system targets associated with preeclampsia and environmental pollutants.
Efflux transporters in drug disposition during pregnancy.
Drug Metab Dispos
January 2025
Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.
Evidence-based dose selection of drugs in pregnant women has been lacking because of challenges in studying maternal-fetal pharmacokinetics. Hence, many drugs are administered off-label during pregnancy based on data obtained from nonpregnant women. During pregnancy, drug transporters play an important role in drug disposition along with known gestational age-dependent changes in physiology and drug-metabolizing enzymes.
View Article and Find Full Text PDFConservative management of placenta accreta spectrum is associated with improved surgical outcomes compared to cesarean hysterectomy: A systematic review and meta-analysis.
Am J Obstet Gynecol
January 2025
Division of Perinatal Surgery and Maternal Fetal Medicine, Department of Obstetrics & Gynecology, Baylor College of Medicine, Houston, TX. Electronic address:
Objective: To compare maternal and surgical outcomes between patients with placenta accreta spectrum (PAS) who underwent conservative management and those who underwent cesarean hysterectomy (CH).
Data Sources: We performed a systematic search in PubMed, Embase and Web of Science from inception up to June 2, 2024.
Study Eligibility Criteria: Studies comparing clinical outcomes among patients with PAS undergoing conservative management versus CH were included.
Successful treatment of subinvolution of the placenta site with uterine artery embolisation, sparing the patient's fertility: A case report.
Case Rep Womens Health
March 2025
Department of Interventional Radiology, Fiona Stanley Hospital, Western Australia, Australia.
Subinvolution of the placental site can lead to severe post-partum haemorrhage, though it is a rare cause of the condition. Subinvolution of the placental site is an abnormal persistence of widely dilated uteroplacental spiral arteries in the absence of retained products of conception, and is associated with an increased risk of maternal morbidity and mortality. This report presents a case of an uneventful caesarean section that was followed by multiple presentations of major secondary post-partum haemorrhage, with a subsequent diagnosis of subinvolution of the placental site on histopathology.
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