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Artificial intelligence for hemodynamic monitoring with a wearable electrocardiogram monitor.
Commun Med (Lond)
January 2025
Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.
Background: The ability to non-invasively measure left atrial pressure would facilitate the identification of patients at risk of pulmonary congestion and guide proactive heart failure care. Wearable cardiac monitors, which record single-lead electrocardiogram data, provide information that can be leveraged to infer left atrial pressures.
Methods: We developed a deep neural network using single-lead electrocardiogram data to determine when the left atrial pressure is elevated.
Highlights of the 2024 Chinese hypertension guidelines.
Hypertens Res
January 2025
Department of Hypertension, Peking University People's Hospital, Beijing, China.
The 2024 Chinese hypertension guidelines has been recently issued by Chinese Hypertension League (CHL), joint with partner societies. Since the 2018 guidelines was released, amount of evidence accumulated, in favor of intensive blood pressure (BP) control. New drugs and devices, innovative concepts and new insights have been introduced into hypertension management.
View Article and Find Full Text PDFTwo-year follow-up of gait and postural control following initiation of recombinant human tripeptidyl intracerebroventricular enzyme replacement therapy in two atypical CLN2 patients.
Sci Rep
January 2025
Division of Metabolic Disorders, CHOC Children's Hospital, Orange, CA, 92868, USA.
Neuronal ceroid lipofuscinosis type 2 (CLN2) is a rapidly progressive neurodegenerative disorder leading to premature mortality. Ambulatory CLN2 patients typically receive standard of care treatment through biweekly intracerebroventricular (ICV) enzyme replacement therapy (ERT) involving recombinant human tripeptidyl peptidase 1, known as cerliponase alfa (Brineura, Biomarin Pharmaceuticals). This study longitudinally assessed the impact of ICV cerliponase alfa ERT on gait, and postural control across a two-year span in two siblings diagnosed with atypical CLN2 disease.
View Article and Find Full Text PDFEffectiveness of , an online group-based self-management fall prevention programme for people with multiple sclerosis: protocol of a randomised controlled trial.
BMJ Open
January 2025
Department of Neurobiology, Care Science and Society, Karolinska Institutet, Stockholm, Sweden.
Introduction: is a manualised self-management fall prevention programme co-developed for and with ambulatory and non-ambulatory people with multiple sclerosis (PwMS). Findings from a feasibility study indicate the necessity of a full-scale randomised controlled trial (RCT).
Methods And Analysis: A parallel-group RCT with a mixed methods process evaluation as well as a cost-effectiveness evaluation will be conducted.
Determining the perceptions and practices of oncologists regarding venous thromboembolism risk assessment in ambulatory cancer patients: A qualitative study.
PLoS One
January 2025
Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
Cancer-associated thrombosis (CAT) can increase morbidity and mortality for cancer patients. Therefore, guidelines recommend predicting VTE risk and thromboprophylaxis for high-risk patients. Many studies critique oncologists' adherence to thromboprophylaxis guidelines for cancer patients.
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