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Use of antipsychotic drugs during radiotherapy in adult cancer patients in Korea: a nationwide retrospective cohort study based on the national health insurance service database.
Radiat Oncol
November 2024
Department of Radiation Oncology, Chung-Ang University College of Medicine, 84 Heukseok-ro, Dongjak-gu, Seoul, 06973, Republic of Korea.
Background: Antipsychotic drugs (APDs) are used for treating mental illnesses and are also used by cancer patients. This study aimed to evaluate APD use in adult cancer patients who received radiotherapy (RT) in South Korea and assess the effects of APD use during RT on survival.
Methods: This retrospective cohort study utilized the National Health Insurance Service database database of Korea.
Drug-Induced Systemic Lupus Erythematosus: A Rare Presentation of Hydralazine-Induced Lupus.
Cureus
October 2024
Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by the production of autoantibodies directed against nuclear and cytoplasmic antigens. SLE can be induced by various medications, such as hydralazine, procainamide, isoniazid, methyldopa, chlorpromazine, quinidine, and minocycline. Hydralazine-induced lupus syndrome was first reported in 1953, and only occurs in 5-10% of patients taking hydralazine.
View Article and Find Full Text PDFThe Legacy of Egas Moniz: Triumphs and Controversies in Medical Innovation.
Cureus
October 2024
Neurology, Emory University, Atlanta, USA.
Article Synopsis
- António Egas Moniz was a pioneering Portuguese neurologist who developed cerebral angiography and the controversial prefrontal leucotomy (lobotomy), earning a Nobel Prize in 1949.
- Lobotomy was initially seen as a breakthrough for severe mental conditions but later faced criticism due to severe side effects, leading to a decline in its use with the introduction of neuroleptics like chlorpromazine.
- Moniz's work sparked important ethical debates about informed consent and the long-term effects of psychiatric procedures, highlighting the need for continuous improvements and ethical standards in mental health treatment.
Effects of antipsychotic drugs during radiotherapy in breast cancer in South Korea: a retrospective cohort study.
Sci Rep
November 2024
Department of Radiation Oncology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Article Synopsis
- * Out of 170,226 patients, only 3361 (1.97%) received APDs, and overall findings showed that APD use was linked to higher mortality rates among these patients, including those without metastasis.
- * Interestingly, patients with a prior psychiatric history and long-term APD use had lower mortality, while those starting APDs during radiotherapy experienced higher mortality, indicating that the reasons for APD use may play a significant role in patient outcomes.
From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling.
Arch Toxicol
September 2024
Division of Toxicology, Wageningen University and Research, Wageningen, The Netherlands.
Cholestasis is characterized by hepatic accumulation of bile acids. Clinical manifestation of cholestasis only occurs in a small proportion of exposed individuals. The present study aims to develop a new approach methodology (NAM) to predict drug-induced cholestasis as a result of drug-induced hepatic bile acid efflux inhibition and the resulting bile acid accumulation.
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