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Article Synopsis
- The article presents a clinical case of a young patient with HPV-associated penile intraepithelial neoplasia (PIN), specifically the erythematous form of bowenoid papulosis.
- It highlights the issues of delayed diagnosis due to improper diagnostic approaches and a lack of awareness among doctors about cancer-related diseases.
- The piece emphasizes the significance of early detection in preventing progression to more severe conditions like squamous cell penile carcinoma, detailing the different subtypes of PIN and their varying risks of leading to cancer.
Zoon balanitis: not a distinct clinicopathological entity?
Clin Exp Dermatol
November 2024
Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, UK.
Zoon balanitis (ZB) was originally described in the 1950s in patients with clinical features resembling erythroplasia of Queyrat, but with histology that demonstrated a plasma cell infiltrate without evidence of dysplasia. Subsequently, ZB has been extensively reported in the literature, reflecting widespread acknowledgement as an established distinct clinicopathological entity. However, its existence as such has been questioned and there have been suggestions in the literature that ZB represents either a non-specific irritant reaction pattern, or a part of the heterogenous clinicopathological complex of male genital lichen sclerosus (MGLSc).
View Article and Find Full Text PDFSquamous Cell Carcinoma In Situ-The Importance of Early Diagnosis in Bowen Disease, Vulvar Intraepithelial Neoplasia, Penile Intraepithelial Neoplasia, and Erythroplasia of Queyrat.
Diagnostics (Basel)
August 2024
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Article Synopsis
- - Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, with early recognition being crucial as delayed diagnosis can lead to more aggressive forms and surgical complications.
- - Bowen's disease (BD) is an early stage of cSCC that shows specific skin features, but histopathology is essential for accurate diagnosis and treatment planning.
- - Diagnosing precancerous conditions like vulvar and penile intraepithelial neoplasia (VIN and PeIN) can be complex, often requiring multiple biopsies and utilizing techniques like immunostaining and HPV testing to guide treatment options.
Cold atmospheric plasma in combination with laser therapy provides a window for the treatment of hyperproliferative skin disease.
Photodiagnosis Photodyn Ther
August 2024
Department of Dermatology and Venereology, the Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei 230601, China; Joint Laboratory for Plasma Clinical Applications, the Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei 230601, China. Electronic address:
Modern medical understanding suggests that hyperproliferative skin diseases (HSDs) are complex syndromes characterized by localized hypertrophy or hyperplasia and infiltration of inflammatory cells. Various treatments, including systemic and topical pharmacotherapy, laser interventions, photodynamic therapy, and surgery, have been proposed for managing HSDs. However, challenges such as wound healing and recurrence after laser treatment have hindered the effectiveness of laser therapy.
View Article and Find Full Text PDFDermoscopy to differentiate clinically similar inflammatory and neoplastic skin lesions.
Ital J Dermatol Venerol
April 2024
Institute of Dermatology, Santa Maria della Misericordia University Hospital, Udine, Italy -
Article Synopsis
- - Dermoscopy is a valuable imaging technique for dermatologists that helps distinguish between neoplastic (tumor-related) and inflammatory skin conditions, especially in tricky cases where they may appear similar.
- - A review of literature identified key dermoscopic features that can aid in differentiating 12 common challenging skin scenarios, such as distinguishing between Bowen's disease and psoriasis.
- - The study concludes that dermoscopy can significantly assist in differentiating between clinically similar skin lesions, improving diagnosis and treatment strategies.
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