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Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.
Clin Transl Oncol
October 2024
Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Purpose: While treatments for primary brain tumors increase survival, they have cognitive sequelae. Neurocognition's anatomical distribution makes it susceptible to brain damage. This study aims to evaluate the contribution of radiotherapy on short-term cognitive impairment.
View Article and Find Full Text PDFCase Report: Contribution of [F]FET PET in differential diagnosis between radionecrosis and progression in metastasis-reproducibility and superiority of dynamic acquisitions.
Front Nucl Med
February 2024
Nuclear Medicine Department, CHRU de Tours, Tours, France.
We present the case of a 67-year-old woman with metastatic invasive ductal carcinoma of the left breast, in whom a follow-up magnetic resonance imaging, 3 months after encephalic radiotherapy, revealed a significant increase in the size of two brain metastases, potentially indicating progressive disease within the radiation field. Subsequent [F] fluorodeoxyglucose ([F]FDG) and [F] fluoroethyl-L-tyrosine positron emission tomography ([F]FET PET) scans were performed to distinguish radionecrosis from tumor progression. Despite a dynamic [F]FET time-activity curve (TAC) against progression, the exceeding of the 1.
View Article and Find Full Text PDFNitric oxide-signalling affects panic-like defensive behaviour and defensive antinociception neuromodulation in the prelimbic cerebral cortex.
Brain Res
December 2024
Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo 14049-900, Brazil; Institute of Neuroscience and Behaviour (INeC) Ophidiarium, Av. Bandeirantes, 3900, Ribeirão Preto, São Paulo 14040-901, Brazil. Electronic address:
Rationale: The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a key structure in panic.
Objectives: To evaluate the role of nitric oxide (NO) in defensive behaviour and antinociception.
Methods: Either Nω-propyl-L-arginine (NPLA) or Carboxy-PTIO was microinjected in the PrL cortex, followed by hypothalamic treatment with bicuculline.
Complete and durable regression of leptomeningeal involvement during lorlatinib treatment in a patient with lung cancer.
Anticancer Drugs
October 2024
Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena.
Metastatic spread to the central nervous system (CNS) is frequent in anaplastic lymphoma kinase ( ALK )-rearranged non-small cell lung cancer (NSCLC) and has an important impact on patient prognosis and quality of life. Leptomeningeal involvement may occur in up to 10% of cases of ALK-positive NSCLC. Lorlatinib is a third-generation ALK inhibitor that has excellent CNS penetrability and demonstrated its efficacy both in pretreated and treatment-naive patients.
View Article and Find Full Text PDFAssociation between the Anatomical Location of Glioblastoma and Its Evaluation with Clinical Considerations: A Systematic Review and Meta-Analysis.
J Clin Med
June 2024
One Health Research Group, Universidad de las Americas, Quito 170124, Ecuador.
Glioblastoma is a primary malignant brain tumor; it is aggressive with a high degree of malignancy and unfavorable prognosis and is the most common type of malignant brain tumor. Glioblastomas can be located in the brain, cerebellum, brainstem, and spinal cord, originating from glial cells, particularly astrocytes. The databases MEDLINE, Scopus, Web of Science, Google Scholar, and CINAHL were researched up to January 2024.
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