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[A Case of Pial Arteriovenous Fistulae Associated with Hereditary Hemorrhagic Telangiectasia].
No Shinkei Geka
May 2020
Department of Neurosurgery, Yuri Kumiai General Hospital.
Pial arteriovenous fistulae(pial AVF)are rare vascular lesions. Pial AVF is a complication of hereditary hemorrhagic telangiectasia(HHT)and is associated with a high mortality rate. Here, we report a case of a 14-year-old boy with pial AVF associated with HHT who presented with a seizure.
View Article and Find Full Text PDFCutaneous manifestations of gastrointestinal disease: part II.
J Am Acad Dermatol
February 2013
Division of Dermatology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA.
The gastrointestinal (GI) and cutaneous organ systems are closely linked. In part I of this continuing medical education article, the intricacies of this relationship were explored as they pertained to hereditary polyposis disorders, hamartomatous disorders, and paraneoplastic disease. Part II focuses on the cutaneous system's links to inflammatory bowel disease and vascular disorders.
View Article and Find Full Text PDFCutaneous side-effects of EGFR inhibitors and their management.
Skin Therapy Lett
January 2011
Department of Dermatology and Allergology, Ludwig-Maximilian-University of Munich, Munich, Germany.
Epidermal growth factor receptor (EGFR) inhibitors are an increasingly important treatment option for metastasized cancer in patients. In addition to the pivotal role of EGFR in the development and progression of malignant tumors, EGFR is also important for proliferation and differentiation of the human epidermis and hair follicles. As a consequence, cutaneous side-effects are frequently observed during cancer therapy with EGFR inhibitors.
View Article and Find Full Text PDFAutopsy study of cerebellar degeneration in siblings with ataxia-telangiectasia-like disorder.
Acta Neuropathol
April 2010
Division of Neurology, Saitama Children's Medical Center, 2100, Magome, Iwatsuki-ku, Saitama, Saitama 339-8551, Japan.
Ataxia-telangiectasia-like disorder (ATLD) is caused by mutations of the MRE11 gene and is characterized by cerebellar ataxia, increased frequency of chromosomal translocations and hypersensitivity to ionizing radiation. ATLD is a rare genetic disease and the associated pathological changes in the brain are unclear. Here, we report the neuropathological findings in the first cases of genetically confirmed ATLD in a pair of Japanese male siblings.
View Article and Find Full Text PDFManagement of cutaneous side-effects of cetuximab therapy in patients with metastatic colorectal cancer.
J Eur Acad Dermatol Venereol
April 2010
Institute of Oncology Ljubljana, Slovenia.
Background: Cetuximab is a chimeric human-murine monoclonal antibody against the epidermal growth factor receptor (EGFR). It has shown activities against multiple malignancies in clinical trials. EGFR-inhibitors (EGFRI) often cause skin toxicity, most frequently acneiform eruption.
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