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Impact of neurally mediated antidiuretic effect relative to pressure diuresis during acute changes in sympathetic nerve activity.
Am J Physiol Regul Integr Comp Physiol
January 2023
Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Suita, Japan.
We examined urine excretion during primary acute sympathetic activation (PASA) in anesthetized Wistar-Kyoto rats. Since arterial pressure (AP) changes with sympathetic nerve activity (SNA) during PASA, urine excretion reflects a neurally mediated antidiuretic effect combined with an effect of pressure diuresis. We hypothesized that preventing AP changes under PASA would enable the direct estimation of the neurally mediated antidiuretic effect alone.
View Article and Find Full Text PDFActivation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus.
Clin Exp Nephrol
October 2021
Department of Nephrology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Background: Congenital nephrogenic diabetes insipidus (NDI) is primarily caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R). Renal unresponsiveness to the antidiuretic hormone vasopressin impairs aquaporin-2 (AQP2) water channel activity and water reabsorption from urine, resulting in polyuria. Currently available symptomatic treatments inadequately reduce patients' excessive amounts of urine excretion, threatening their quality of life.
View Article and Find Full Text PDFEvaluation of Phytochemicals and Bioactive Properties in Mangrove Associate . ex J.F.Gmel. of Indian Sundarbans.
Front Pharmacol
March 2021
Department of Microbiology, Bose Institute, Kolkata, India.
Suaeda monoica Forssk. ex J.F.
View Article and Find Full Text PDFCopeptin, a surrogate marker of arginine vasopressin, has no ability to modulate human and mouse gastric motility.
Eur J Pharmacol
February 2021
Bariatric Surgery Department, Homerton University Hospital, London, United Kingdom.
Copeptin, a glycosylated peptide fragment derived from the C-terminal region of the precursor of arginine vasopressin (AVP), is co-secreted with AVP in equimolar amounts. Elevated plasma AVP modulates gastric motility so we investigated whether copeptin had a similar effect. Copeptin (10-10M), and AVP (10-10M), were evaluated for their ability to modulate spontaneous and electrically-evoked (EFS) contractions of human proximal and distal gastric circular muscle in vitro.
View Article and Find Full Text PDFLuteolin, a Potent Human Monoamine Oxidase-A Inhibitor and Dopamine D and Vasopressin V Receptor Antagonist.
J Agric Food Chem
September 2020
Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.
Luteolin, a flavonoid widely distributed in the plant kingdom, contains two benzene rings and hydroxyl groups, and this structural specificity contributes to its diverse biological activities. However, no previous studies have simultaneously investigated the therapeutic potency of luteolin isolated from a plant as an antipsychotic and antidepressant. Here, luteolin exhibited selective inhibition of hMAO-A (IC = 8.
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