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Diagnosis and treatment of Hymenoptera venom allergy: S2k Guideline of the German Society of Allergology and Clinical Immunology (DGAKI) in collaboration with the Arbeitsgemeinschaft für Berufs- und Umweltdermatologie e.V. (ABD), the Medical Association of German Allergologists (AeDA), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Allergy and Environmental Medicine (GPA), German Respiratory Society (DGP), and the Austrian Society for Allergy and Immunology (ÖGAI).
Allergol Select
October 2023
Department of Dermatology and Allergology, University Hospital Giessen, Justus Liebig University Gießen, Gießen, Germany.
Article Synopsis
- Hymenoptera venom (HV), injected by bees and wasps during stings, can cause allergic reactions in about 3% of people, leading to severe local or systemic allergic reactions in some cases.
- The guidelines suggest that while symptomatic therapy is needed after a severe local reaction, specific allergen immunotherapy isn't necessary unless severe reactions occur beyond the skin.
- Clinicians should assess patients for risk factors, measure tryptase levels if reactions are significant, and test for specific IgE antibodies to diagnose sensitization to Hymenoptera venom.
Allergic Complications of Hyaluronidase Injection: Risk Factors, Treatment Strategies, and Recommendations for Management.
Aesthetic Plast Surg
February 2024
Division of Allergy and Immunology, Department of Otolaryngology, The Ohio State University, 915 Olentangy River Rd, Columbus, OH, 43212, USA.
Background: Hyaluronidase is used as a reversal agent for hyaluronic acid fillers and to increase the diffusion of other medications after infiltration. Cases of hyaluronidase allergy have been described in the literature since 1984. However, it is still frequently misdiagnosed.
View Article and Find Full Text PDFLocalised swelling at sites of dermal filler injections following administration of Covid-19 vaccines: a systematic review.
Singapore Med J
December 2024
Department of Otolaryngology, Lewisham and Greenwich NHS Trust, London, United Kingdom.
Introduction: Localised swelling at sites of filler injections has been reported in the Moderna mRNA-1273 coronavirus disease 2019 (COVID-19) vaccine trial.
Methods: We conducted a review of the existing data and literature on the potential pathophysiology for this adverse event and its potential management.
Results: Data from the Moderna and Pfizer COVID-19 vaccine Phase 3 trial and one case series were available.
Case report of possible iatrogenic Cushing's disease with low-dose prednisone to treat dermal filler hypersensitivity.
J Cosmet Dermatol
December 2022
Department of Oral & Maxillofacial Surgery, Faculdade Patos de Minas, Brasília, Brazil.
Objectives: The aim of this article is to report a case of iatrogenic Cushing's disease associated with a delayed inflammatory response due to a facial dermal filler procedure.
Methods: A case report according to CARE guidelines was performed. A delayed inflammatory reaction due to dermal filler injection resulted in iatrogenic Cushing's disease in a patient with no comorbidities or allergies.
Recombinant human hyaluronidase PH20-mediated dermal spreading activity in mice is not altered by steroids, antihistamines, or salicylic acid.
Drug Metab Pers Ther
December 2020
Halozyme Therapeutics Inc., San Diego, CA, USA.
Objectives: Drug-drug interaction studies for hyaluronidase safety assessments have evaluated only animal-derived enzyme preparations. We therefore set out to evaluate whether high-dose administration of two antihistamines, a potent corticosteroid, steroid hormone, adrenocorticotropic hormone (ACTH), or salicylic acid would alter the dispersive activity of recombinant human hyaluronidase PH20 (rHuPH20).
Methods: NCr nu/nu mice were pretreated with diphenhydramine, cetirizine, dexamethasone, estrogen, ACTH, salicylic acid, and/or neutral-buffered saline (NBS).
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