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Haploid like spermatid generation by transplantation of neonatal mouse testicular tissue into the epididymal fat of castrated adult mouse.
JBRA Assist Reprod
January 2025
Department of Anatomical Sciences, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran.
Objective: Many cancer survivors may experience irreversible infertility due to chemotherapy treatment for childhood cancer. In this study, spermatogenesis development was evaluated following the grafting of fresh and frozen-thawed testicular tissue from neonatal mice to the epididymal fat of adult mice.
Methods: After bilateral castration of recipient mice, fresh or frozen-thawed neonatal testis tissues were grafted into the epididymal fat of the mice.
Sex-specific efficacy of deslorelin in downregulating reproductive activity in the grey mouse lemur ().
Anim Reprod
November 2024
Unité Mécanismes Adaptatifs et Evolution (MECADEV), UMR 7179, CNRS, Muséum national d'Histoire naturelle, Brunoy, France.
Deslorelin is a GnRH agonist used in veterinary medicine to temporarily inhibit reproduction in domestic animals and is sometimes tested in captive species in zoo to control population or tame aggressive behaviours in males. However, some studies have revealed the inefficacy of deslorelin specifically in males, contrary to females that follow a classic long-term inhibition of the reproductive hypothalamic-pituitary axis through sexual steroid negative feedback. We implanted 5 males and 6 females grey mouse lemurs (), long-day breeders that display a complete inhibition of the reproductive system during winter, at the end of the short-day period, a few weeks before the breeding season.
View Article and Find Full Text PDFSex-Linked Differences in Cardiac Atrophy After Heterotopic Heart Transplantation: No Direct Relation to the Actions of Sex Steroid Hormones.
Physiol Res
November 2024
Dept Cardiovasc Surgery, Inst Clin Exp Med, Prague, Czech Republic.
An important complication of prolonged support of the left ventricle with an assist device when implanted in patients with heart failure is unloading-induced cardiac atrophy. Our recent study suggested that sex-linked differences in the development of atrophy induced by heterotopic heart transplantation (HTX) do exist, however, the role of the environmental conditions dependent on plasma concentrations of sex hormones remains elusive. We aimed to compare the course of HTX-induced cardiac atrophy in male and female rats after gonadectomy with substitution of steroid hormones of the opposite sex.
View Article and Find Full Text PDFSuccessful hormonal and chemical induction of prostate cancer in a rat model: practical guidelines.
Vet Res Forum
September 2024
Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
Prostate cancer is a very common cancer in men, affecting approximately 1.40 million men worldwide in 2020. To improve the quality of life and survival of both animals and humans, effective therapeutic approaches have been developed and evaluated using animal models.
View Article and Find Full Text PDFInhibition of testicular development by suppressing neonatal LH rise in male domestic pigs.
Anim Reprod Sci
November 2024
Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA; Epivara, Inc., Champaign, IL, 61820, USA. Electronic address:
The neonatal increase in circulating luteinizing hormone (LH) is crucial for testicular development. In male pigs, blood LH levels start to increase approximately 1 week after birth and return to basal level by 5-6 weeks of age. This study tested the hypothesis that neonatal treatment with a combination of estrogens and androgens suppresses LH secretion and thereby inhibits testicular development.
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