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Pemetrexed is a chemotherapeutic, antimetabolite agent that has been used in oncology to treat diseases such as metastatic non-small cell lung cancer and unresectable malignant pleural mesothelioma. Pemetrexed use may result in pseudocellulitis, which presents as poorly demarcated patches or plaques with erythema, edema, warmth, and tenderness. These lesions can present unilaterally or bilaterally on the lower extremities.

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Results of treating patients with cellulitis by hyperbaric oxygen: a case-control study.

Int Marit Health

January 2025

Institute of Maritime Medicine, Hai Phong, Vietnam, 21 Vo Nguyen Giap, Le Chan, Kenh Duong, Hai Phong, Vietnam, 18000 Hai Phong, Viet Nam.

Background: Cellulitis is an acute bacterial infection of the skin and subcutaneous tissue. The characteristic symptoms of the disease are an area of skin that is swollen, warmth, redness, pain, unknown borderline, tends to expand, and can lead to tissue necrosis. Hyperbaric Oxygen (HBO) is a non-drug treatment, which has the effect of relieving pain, reducing edema, and accelerating the wound healing process for patients with cellulitis.

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Article Synopsis
  • Necrotising fasciitis (NF) is a serious, fast-spreading infection known as "flesh-eating disease," primarily affecting soft tissues and leading to skin necrosis.
  • An elderly male developed periorbital NF after a minor head injury, showing symptoms like swelling and discharge, with a rare pathogen identified as the cause.
  • The treatment involved antibiotics, surgery, and skin grafting, resulting in significant recovery, highlighting the need for quick diagnosis and intervention to avoid severe outcomes.
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: Dermatological complaints are commonly seen in the emergency department (ED) setting and may be attributed to infectious, inflammatory, allergic, hypersensitivity, or traumatic processes, yet few studies have been carried out in Saudi Arabia addressing this topic. This study, therefore, aimed to explore this issue by investigating the most common dermatology-related ED encounters in a large tertiary care center in Riyadh, Saudi Arabia, and estimating the incidence of these encounters. : This was a retrospective cohort study conducted in the ED of King Abdulaziz Medical City, a tertiary care center in Riyadh, Saudi Arabia.

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