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Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt.
PLoS Pathog
January 2025
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.
The intracellular protozoan Toxoplasma gondii manipulates host cell signaling to avoid targeting by autophagosomes and lysosomal degradation. Epidermal Growth Factor Receptor (EGFR) is a mediator of this survival strategy. However, EGFR expression is limited in the brain and retina, organs affected in toxoplasmosis.
View Article and Find Full Text PDFUnusual cholesterol crystal formation in a rare clinical case report of splenic echinococcal cyst in a patient from Sardinia, Italy.
Front Parasitol
January 2025
World Organisation for Animal Health (WOAH) and National Reference Laboratory for Echinococcosis, Istituto Zooprofilattico della Sardegna, Sassari, Italy.
Cystic echinococcosis (CE) is a zoonotic disease caused by sensu lato, the metacestode of a tapeworm parasite of high medical importance. Infection of the parasite leads to the development of echinococcal cysts, and the spleen is a rarely infected organ. A 46-year-old woman who was born and who resides in Sardinia, Italy, was referred to the Echinococcosis outpatient clinic at the University Hospital of Sassari (Sardinia, Italy) for a pain in the left flank.
View Article and Find Full Text PDFSpinal schistosomiasis masquerading as spinal cord tumor in a 12-year-old male adolescent: A case report.
Radiol Case Rep
March 2025
School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Spinal schistosomiasis, a rare manifestation of schistosomal infection, can closely mimic the presentation of spinal cord tumors and pose significant diagnostic challenges. We present the case of a 12-year-old boy from northern Ethiopia who experienced progressive back pain, tingling sensations in his lower extremities, and intermittent fever. Initially referred with a presumptive diagnosis of myxopapillary ependymoma for pediatric hematology-oncology evaluation, his marked eosinophilia and history of swimming in local rivers raised suspicion for spinal schistosomiasis.
View Article and Find Full Text PDFCauses of mortality and morbidity in the endangered southern brown bandicoot (Isoodon obesulus obesulus).
Aust Vet J
January 2025
Melbourne Veterinary School, Faculty of Science, The University of Melbourne, Parkville, Victoria, 3052, Australia.
Unlabelled: The southern brown bandicoot (Isoodon obesulus obesulus) is a small, endangered, Australian, ground-dwelling marsupial. Apart from isolated necropsy reports, there has not been a systematic investigation into the health and causes of death for this species.
Objective: To investigate and document the causes of death and the parasites of free-ranging populations of southern brown bandicoots in southern, central Victoria, Australia.
Selective activity of Tabebuia avellanedae against Giardia duodenalis infecting organoid-derived human gastrointestinal epithelia.
Int J Parasitol Drugs Drug Resist
January 2025
Department of Infectious Diseases, Unit of Foodborne and Neglected Parasitic Diseases, Istituto Superiore di Sanità, viale Regina Elena 299, Rome, Italy. Electronic address:
Giardia duodenalis is a widespread intestinal protozoan that affects mammals, including humans. Symptoms can range from being subclinical to causing severe abdominal pain and diarrhoea. Giardiasis often requires repeated treatment with synthetic drugs like metronidazole.
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