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Altered Effective Connectivity Within a Thalamocortical Corollary Discharge Network in Individuals With Schizophrenia.
Schizophr Bull
January 2025
Psychology, Michigan State University, East Lansing, MI, 48824, United States.
Background And Hypothesis: Sequential saccade planning requires corollary discharge (CD) signals that provide information about the planned landing location of an eye movement. These CD signals may be altered among individuals with schizophrenia (SZ), providing a potential mechanism to explain passivity and anomalous self-experiences broadly. In healthy controls (HC), a key oculomotor CD network transmits CD signals from the thalamus to the frontal eye fields (FEF) and the intraparietal sulcus (IPS) and also remaps signals from FEF to IPS.
View Article and Find Full Text PDFPredicting enthalpy of formation of benzenoid hydrocarbons and ordering molecular trees using general multiplicative Zagreb indices.
Heliyon
May 2024
Department of Computer and Information Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.
Many existing studies show that there exists a strong relationship between structures and characteristics of molecules. Topological indices are often used in modeling the properties of chemical compounds and biological activities in theoretical chemistry. Topological indices are numerical values associated with structures of molecules in such a way that they remain constant under graph isomorphism.
View Article and Find Full Text PDFLarge property models: a new generative machine-learning formulation for molecules.
Faraday Discuss
January 2025
Department of Chemical and Biomolecular Engineering, The University of Notre Dame, Notre Dame, Indiana, USA.
Article Synopsis
- Generative models for designing molecules have not shown significant improvements over traditional expert intuition, particularly in predicting specific properties due to limited data availability.
- A major challenge is that there are often very few samples for desired properties, making it hard to accurately map properties to molecular structures.
- The authors propose that providing multiple properties during training can enhance the accuracy of generative models, leading to new models they call "large property models" (LPMs) which incorporate a wealth of available chemical property data to improve predictions.
A multi-national survey to identify health professionals' opinions for the appropriate frequency of urine output monitoring in post-operative patients.
J Intensive Care Soc
February 2024
University Hospitals Sussex, Chichester, UK.
Urine output is an important clinical measurement and oliguria may highlight the development of acute kidney injury (AKI) earlier than serum creatinine (sCr). Despite the importance of urine output monitoring, there are no definitive guidelines or recommendations for best practice. A survey was sent to healthcare professionals with a specialist interest in AKI to gather opinions of what constitutes a good standard of urine output monitoring and by corollary missed care, post- major surgery.
View Article and Find Full Text PDFPhagolysosomal resistance hypothesized to be a danger signal.
Scand J Immunol
October 2024
Mountain View, California, USA.
Antigen presenting cells sometimes require T cell "help" to kill and decompose microbes they capture, especially when those microbes resist effector molecules including nitric oxide and reactive oxygen species. Pathogens are more likely to resist those effectors, shared by the innate and adaptive immune systems, than are commensals. Does such resistance alert the immune system to the danger posed by those pathogens? Several lines of evidence suggest this occurs.
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