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Study on the Effect of Bee Venom and Its Main Component Melittin in Delaying Skin Aging in Mice.
Int J Mol Sci
January 2025
College of Animal Science, Shanxi Agricultural University, Taigu 030801, China.
Bee venom (BV) and its main compound melittin (MLT) have antioxidant, anti-inflammatory, and anti-aging activities; however, very little research has been conducted on their effects on skin aging. In this study, a mouse skin aging model induced by D-galactose was constructed via subcutaneous injection into the scruff of the neck, and different doses of BV and MLT were used as interventions. The anti-aging effects and mechanisms of BV and MLT were explored by detecting the skin morphology and structure, and anti-aging-related factors and performing non-targeted metabolomics of mice.
View Article and Find Full Text PDFEnhancing Industrial Hemp () Leaf By-Products: Bioactive Compounds, Anti-Inflammatory Properties, and Potential Health Applications.
Int J Mol Sci
January 2025
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 53100 Siena, Italy.
The sustainable utilization of biomass-derived bioactives addresses the growing demand for natural health products and supports sustainable development goals by reducing reliance on synthetic chemicals in healthcare. biomass, in particular, has emerged as a valuable resource within this context. This study focuses on the hydroethanolic extract of leaves (CSE), which exhibited significant levels of phenolic compounds contributing to robust antioxidant activity.
View Article and Find Full Text PDFEffects of Hyaluronic Acid on Three Different Cell Types of the Periodontium in a Novel Multi-Culture Cell Plate: An Exploratory Study.
Biomolecules
January 2025
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The Netherlands.
Hyaluronic acid (HA) has received considerable attention in the reconstruction of lost periodontal tissues. HA has been proposed to play a role in cell proliferation, differentiation, migration, and cell-matrix as well as cell-cell interactions. Although various studies have been conducted, further research is needed to expand our knowledge based on HA such as its effects on cell proliferation and osteogenic differentiation.
View Article and Find Full Text PDFImpact of Hyaluronic Acid on the Cutaneous T-Cell Lymphoma Microenvironment: A Novel Anti-Tumor Mechanism of Bexarotene.
Cancers (Basel)
January 2025
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Background: Cutaneous T-cell lymphoma (CTCL) is a type of non-Hodgkin's lymphoma that primarily affects the skin, rich in hyaluronic acid (HA). HA is a component of the extracellular matrix in the dermis and likely affects the development of CTCL, but the mechanism is poorly understood. Here we show that low-molecular-weight HA (LMWHA) possibly exacerbates CTCL, and bexarotene, already used in CTCL treatment, decreases HA production.
View Article and Find Full Text PDFEmerging trends in designing polysaccharide based mucoadhesive network hydrogels as versatile platforms for innovative delivery of therapeutic agents: A review.
Int J Biol Macromol
January 2025
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India. Electronic address:
Introduction: The rapid progress in polymer science has designed innovative materials for biomedical applications. In the case of drug design, for each new therapeutic agent, a drug delivery system (DDS) is required to improve its pharmacokinetic and pharmacodynamic parameters. Therefore, significant research has been carried out to develop drug delivery (DD) carriers for these new therapeutic agents.
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