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Dietary arabinogalactan modulates immunity and improves gut barrier in broilers via regulating metabolome and gut microbiome.
Carbohydr Polym
March 2025
State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. Electronic address:
The extraction of polysaccharides from wood by-products is recognized as a green re-utilization approach to shape a recycling-oriented society. In this research, we identified the structural properties of arabinogalactan (AG) extracted from Larix sibirica Ledeb wood chips and verified its efficacy as an additive in broiler framing. Results showed that the molecular weight of AG is 19.
View Article and Find Full Text PDFFree fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota.
Nat Microbiol
January 2025
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Sugar preference is a key contributor to the overconsumption of sugar and the concomitant increase in the incidence of diabetes. However, the exact mechanism of its development remains ambiguous. Here we show that the expression of free fatty acid receptor Ffar4, a receptor for long-chain fatty acids, is decreased in patients and mouse models with diabetes, which is associated with high sugar intake.
View Article and Find Full Text PDFMetabolomics Analysis Using Chromatography-Mass Spectrometry to Investigate the Mechanism of Cyclosporine in the Treatment of Aplastic Anemia.
Rapid Commun Mass Spectrom
March 2025
Department of Pharmacy, The Affiliated Yixing Clinical School of Medical School of Yangzhou University, Yixing, China.
Objective: The aim of this study was to use metabolomics techniques to detect differential metabolites in the plasma of patients with aplastic anemia (AA). We explore important biomarkers and potential pathways in cyclosporine A (CsA) in the treatment of AA.
Methods: Plasma samples from five patients with AA before and after treatment and plasma samples from five healthy people were collected and analyzed by liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry.
In silico study of bioactive compounds derived from Indonesian marine invertebrates as a novel antituberculosis agent.
Turk J Med Sci
December 2024
Research Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, Bogor, Indonesia.
Background/aim: Tuberculosis (TB) has become the world's deadliest disease. The lack of an effective therapeutic drug to treat it is one of the obstacle for doctors. Today, multidrug-resistant TB cases are increasing.
View Article and Find Full Text PDFElucidating metabolic pathways through genomic analysis in highly heavy metal-resistant strains.
Heliyon
December 2024
Research Laboratory of Environmental Sciences and Sustainable Development, LR18ES32, University of Sfax, Tunisia.
The annotated and predicted genomes of five archaeal strains (AS1, AS2, AS8, AS11 and AS19), isolated from Sfax solar saltern sediments (Tunisia) and affiliated with , were performed by RAST webserver (Rapid Annotation using Subsystem Technology) and NCBI prokaryotic genome annotation pipeline (PGAP). The results showed the ability of strains to use a reduced semi-phosphorylative Entner-Doudoroff pathway for glucose degradation and an Embden-Meyerhof one for gluconeogenesis. They could use glucose, fructose, glycerol, and acetate as sole source of carbon and energy.
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