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Simultaneous detection of dengue virus serotypes in a dual-serotype-detection nucleic acid based lateral flow assay.
Diagn Microbiol Infect Dis
January 2025
Department of Anatomy, Jajati Keshari Medical College and Hospital, Jajpur, Odisha, India.
Dengue virus (DENV) is an important arthropod-borne viral disease, with four antigenically and genetically diverse serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). Timely and accurate diagnosis of dengue virus serotypes is crucial for the management of outbreaks. This study focussed on the development of a RT-PCR based lateral flow strip assay to detect DENV serotypes in a dual detection manner without using gel electrophoresis.
View Article and Find Full Text PDFClinical and Laboratory Features and Treatment Outcomes of Dengue Fever in Pediatric Cases.
Cureus
December 2024
Department of Pharmacology and Therapeutics, National Defence University of Malaysia, Kuala Lumpur, MYS.
Background Globally, dengue fever (DF) is the leading cause of arthropod-borne viral illness, which considerably contributes to an atrocious death rate. The disease is now endemic in some parts of the world, including Bangladesh. The disorder exhibits a wide range of clinical and laboratory features in children.
View Article and Find Full Text PDFLow-density Lipoprotein Receptor is an important host factor in flaviviral entry and replication in neurons.
Biochem Biophys Res Commun
January 2025
National Brain Research Centre, Manesar, Haryana, 122052, India. Electronic address:
Flaviviruses, which are transmitted by mosquitoes, are arthropod-borne infections that are pathogenic to both humans and animals, posing a significant global threat to public health. So far, various endocytic pathways have been reported for flaviviral entry; however, the role of cellular factors in viral replication and entry remains uncertain. Here in this study, we identified the role of Low-density lipoprotein receptor, which has long been established as a cholesterol carrier for neurons but remained unexplored as an essential host factor for JEV/WNV replication.
View Article and Find Full Text PDFBunyaviruses: Expression of Recombinant Glycoproteins from Insect Cells.
Methods Mol Biol
December 2024
Wageningen Bioveterinary Research (WBVR), RA, Lelystad, The Netherlands.
High-density suspension cultures of insect cells offer a scalable and serum-free system for the expression of recombinant proteins. Rift Valley fever virus (RVFV), an arthropod-borne virus spread by mosquitoes, contains two envelop glycoproteins Gn and Gc. These glycoproteins are crucial for eliciting neutralizing antibodies that can offer protection against RVFV infection.
View Article and Find Full Text PDFArticle Synopsis
- - Flaviviruses are a group of viruses that cause serious diseases in humans, including dengue and Zika, and rely on a protein called NS1 for replication and disease severity.
- - NS1 is secreted from infected cells and contributes to endothelial dysfunction, which affects blood vessel permeability and may facilitate the spread of the virus in the body.
- - Research demonstrates that NS1 aids in the virus's ability to cross endothelial barriers and boosts the infectivity of specific target cells, indicating its crucial role in virus dissemination and its impact on disease progression.
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