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Clinical, Laboratory Aspects and Management of Factor X Deficiency.
Semin Thromb Hemost
August 2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan, Italy.
Article Synopsis
- - Coagulation factor X (FX), crucial for blood clotting, activates thrombin and helps prevent excessive bleeding; genetic variants can lead to FX deficiency, which is linked to severe bleeding disorders.
- - FX deficiency can be classified as type I (reduced FX activity and antigen levels) or type II (normal antigen but reduced activity), leading to a variable bleeding tendency that can cause life-threatening symptoms.
- - Treatment for FX deficiency has evolved from traditional methods like fresh frozen plasma to safer plasma-derived concentrates, with emerging therapies like gene therapy and drug repurposing requiring further research.
Arg-Specific serine Protease-Targeted edoxaban tosylate monohydrate-Poly (lactic-co-glycolic acid) Nanoparticles: Investigating Stuart-Prower factor targeting and intestinal distribution through Ex-Vivo fluorescent visualization.
Eur J Pharm Biopharm
October 2024
Crescent School of Pharmacy, B.S.Abdur Rahman Crescent Institute of Science & Technology, Chennai, Tamilnadu 600048, India. Electronic address:
The goal of the current study was to formulate and examine the potential of poly (lactic-co-glycolic acid) (PLGA) as carriers to facilitate the targeted administration of edoxaban tosylate monohydrate (ETM). ETM-PLGA-NPs were effectively formulated using the nanoprecipitation technique. Particle size, drug entrapment percentage, zeta potential, assessment of intestinal absorption, FT-IR, SEM, drug dissolution behavior, and histopathology investigations were used to describe ETM-PLGA-NPs.
View Article and Find Full Text PDFEdoxaban enfolded beta-1,4-poly-d-glucosamine nanoparticles for targeting eponym Stuart-Prower factor for treatment of venous thrombosis.
J Drug Target
November 2024
Crescent School of Pharmacy, B.S.Abdur Rahman Crescent Institute of Science & Technology, Vandalur, India.
The present research looked for ways to develop shielded nanoparticles (NPs)-drug transporters made of chitosan (CS) to enhance the bioavailability of edoxaban tosylate monohydrate (ETM) for oral administration by examining the correlation among design aspects and data from experiments using response surface methodology (RSM). ETM-loaded CS nanoparticles (ETM-CS-NPs) were developed using the ionic gelation of CS with tripolyphosphate (TPP). Utilising Zeta-sizer and scanning electron microscopy, the ETM-CS-NPs were evaluated for particle size (PS), zeta potential (ZP), surface morphology, polydispersity index (PDI), entrapment efficiency (EE) and drug loading (DL).
View Article and Find Full Text PDFThe Role of Coagulation in Heart Failure: A Literature Review.
Curr Heart Fail Rep
August 2024
Department of Zoology (Molecular Physiology), Lahore College for Women University, Lahore, Pakistan.
Purpose Of Review: This article summarizes the role of coagulation factors in the pathophysiology of heart failure including D-dimer, fibrinogen and fibrin, prothrombin, p-selectin, tissue factor, tissue plasminogen activator, von Willebrand factor, β-thromboglobulin, Factor XI, tissue thromboplastin, plasminogen activator inhibitor-1 (PAI-1), thrombomodulin, soluble urokinase-type plasminogen activator receptor (suPAR) and stuart-prower factor.
Recent Findings: The D-dimer, P-selectin, prothrombin, von Willebrand factor, tissue plasminogen activator, fibrinogen, suPAR, tissue factor, thrombomodulin and Factor XI play significant roles the pathophysiology of heart failure. However, no associations were found between β-thromboglobulin, tissue thromboplastin, PAI-1 and stuart-prower factor in the context of heart failure.
Irregularities of Coagulation in Hypertension.
Curr Hypertens Rep
October 2023
Department of Biotechnology (Human Genetics), Lahore College for Women University, Lahore, Punjab, Pakistan.
Purpose Of Review: This review article summarizes the role of coagulation in the pathogenesis of hypertension. It specifically focuses on significant factors and markers associated with coagulation, including D-dimer, fibrinogen and fibrin, prothrombin, P-selectin, soluble urokinase plasminogen activator receptor, thrombomodulin, tissue factor, tissue plasminogen activator, von Willebrand factor, β-thromboglobulin, and Stuart-Prower factor.
Recent Findings: D-dimer levels were elevated in hypertensive individuals compared to healthy controls, and the levels increased with the severity of hypertension.
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