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Background: In Germany, the incidence of traumatic spinal cord injury is approximately 16 per million inhabitants per year. This article aims to present evidence-based diagnostic and therapeutic measures for the first 14 days after injury to minimize neural damage, prevent complications, and preserve functioning as much as possible.
Methods: After the formulation of key questions, systematic literature searches were carried out on multiple topics.
Itaconate restrains acute proinflammatory activation of microglia MG after traumatic brain injury in mice.
Sci Transl Med
March 2025
Clinical Neuroscience Research Center, Department of Neurosurgery and Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Traumatic brain injury (TBI) rapidly triggers proinflammatory activation of microglia, contributing to secondary brain damage post-TBI. Although the governing role of energy metabolism in shaping the inflammatory phenotype and function of immune cells has been increasingly recognized, the specific alterations in microglial bioenergetics post-TBI remain poorly understood. Itaconate, a metabolite produced by the enzyme aconitate decarboxylase 1 [IRG1; encoded by immune responsive gene 1 ()], is a pivotal metabolic regulator in immune cells, particularly in macrophages.
View Article and Find Full Text PDFCan Electroencephalography-Based Neurofeedback Treat Post-traumatic Stress Disorder? A Meta-analysis Study.
Appl Psychophysiol Biofeedback
March 2025
BYU Online High School, Provo, USA.
Post-traumatic stress disorder (PTSD) remains a significant clinical challenge with limited treatment options. Although electroencephalogram (EEG) neurofeedback has garnered attention as a prospective treatment modality for PTSD, no comprehensive meta-analysis has been conducted to assess its efficacy and compare different treatment protocols. This study aims to provide a multi-variable meta-regression analysis of EEG neurofeedback's impact on PTSD symptoms, while also assessing variables that may influence treatment outcomes.
View Article and Find Full Text PDFMultimodal neuromonitoring in the nordic countries: experiences and attitudes - a multi-institutional survey.
Acta Neurochir (Wien)
March 2025
Department of Neurosurgery, Aalborg University Hospital, Aalborg, Denmark.
Background: Multimodal neuromonitoring (MMM) aids early detection of secondary brain injury in neurointensive care and facilitates research in pathophysiologic mechanisms of the injured brain. Invasive ICP monitoring has been the gold standard for decades, however additional methods exist (aMMM). It was hypothesized that local practices regarding aMMM vary considerably and that inter-and intracenter consensus is low.
View Article and Find Full Text PDF3D-printed prosthesis for traumatic trapezium bone defect: a case report.
Arch Orthop Trauma Surg
March 2025
Department of Orthopaedics, Zhangqiu People's Hospital, Zhangqiu, China.
This case report describes a two-stage surgical approach for managing a traumatic defect of the left trapezium bone. A 51-year-old male presented following a high-impact injury caused by a heavy iron object striking his left wrist. The patient reported severe wrist pain and restricted thumb motion.
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