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Effect of infection on immunotherapy for gastrointestinal cancer: a narrative review.
Immunotherapy
March 2025
Department of Medical Oncology, Metaxa Cancer Hospital of Piraeus, Piraeus, Greece.
Immunotherapy for gastrointestinal cancers has elicited considerable amount of attention as a viable therapeutic option for several cancer types. Gut microbiome as a whole plays a critical role in shaping immune responses and influencing cancer progression. Recent evidence suggests that (), may influence immunotherapy efficacy by modulating the tumor microenvironment.
View Article and Find Full Text PDFThe Genetics of IgA Nephropathy: Implications for Future Therapies.
Semin Nephrol
March 2025
Renal Division, Peking University First Hospital, Beijing, People's Republic of China; Kidney Genetics Center, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People's Republic of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, People's Republic of China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, People's Republic of China. Electronic address:
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a considerable lifetime risk of kidney failure. The etiology of IgAN, however, remains incompletely understood, and effective treatment is lacking. Although the multihit model effectively identifies key steps in IgAN development and, to date, provides the best description of IgAN pathogenesis, it remains under development to fully capture the complexity of immune system dysregulation.
View Article and Find Full Text PDFEmerging Biochemical and Immunologic Mechanisms in the Pathogenesis of IgA Nephropathy.
Semin Nephrol
March 2025
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL.
IgA nephropathy is a mesangioproliferative glomerular disease with significant morbidity and mortality. Most patients with IgA nephropathy develop kidney failure in their lifetime, reducing their life expectancy by a decade. Since its first description in 1968, it has been established that kidneys of IgA nephropathy patients are injured as "innocent bystanders" by nephritogenic IgA1-containing immune complexes.
View Article and Find Full Text PDFCorrigendum to "Genetically engineered integrated aflatoxin B1 and deoxynivalenol bispecific nanobody as surrogate antigens for constructed time resolved immune dual detection methods" [Biosens. Bioelectron. 273 (2025) 117137].
Biosens Bioelectron
March 2025
Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs; Laboratory of Risk Assessment for Oilseed Products (Wuhan), Ministry of Agriculture and Rural Affairs; Quality Inspection and Test Center for Oilseed Products, Ministry of Agriculture and Rural Affairs; Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, 430062, China; Food Safety Research Institute, HuBei University, Wuhan, China. Electronic address:
Successful Liver Transplantation After Achieving Complete Clinical Remission of Hepatocellular Carcinoma With Combination Therapy of Immune Checkpoint Inhibitors and Targeted Agents: A Case Report.
Transplant Proc
March 2025
Graduate School of Bengbu Medical University, Bengbu Medical University, Bengbu, Anhui, China; Department of Liver Transplantation, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, China. Electronic address:
Immunotherapy, primarily with immune checkpoint inhibitors, has become pivotal in the treatment of advanced hepatocellular carcinoma (HCC), leading to significant tumor burden reduction. However, its applicability in liver transplantation remains controversial. Due to the potential risks of rejection limiting large-scale clinical trials and the incomplete understanding of underlying mechanisms, whether transplant recipients can benefit from immunotherapy remains uncertain.
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