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[Effect of Tomanol on the analgesic requirements and digestive transit in the postoperative course].
Rev Chir Oncol Radiol O R L Oftalmol Stomatol Chir
July 1987
A case of gangrene of the hand following inadvertent intra-arterial injection of a pyrazole derivative (Tomanol) is presented. Gangrene of the hand and superficial sloughing of the distal arm necessitated a forearm amputation. Because of the serious sequelae, precautions must be taken to avoid inadvertent intra-arterial injections and due consideration must be given to the anatomical variation of the brachial artery and its branches in the cubital fossa.
View Article and Find Full Text PDFEffect of Tomanol on the pharmacokinetics and tissue distribution of penicillin G in dairy cows.
Vet Q
January 1982
Department of Pharmacology, University of Nijmegen, 6500 HB Nijmegen, the Netherlands.
Following concomitant intravenous administration of Tomanol and sodium penicillin G to six Dutch Friesian dairy cows a significant decrease in total body clearance of penicillin (34.7%) and a prolongation of the elimination half-life of penicillin (17.2%) was observed.
View Article and Find Full Text PDFA randomized double-blind study of 40 patients with migraine attacks was carried out to compare an intravenous injection of isopyrine 240 mg plus phenylbutazone 130 mg (Tomanol; Byk-Gulden) with a placebo. Isopyrine is an analgesic with a central sedative action which potentiates the action of phenylbutazone, an inhibitor of prostaglandin biosynthesis and circulation. In 15 patients who received the drug the migraine attack was terminated within 5 minutes of administration, apart from a mild residual headache in 2 cases.
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