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The quest for color-pure emitters for multicolor bioimaging as well as for ultrahigh definition organic light-emitting diodes demands facile design concepts to avoid tedious synthetic or computational trial-and-error procedures. We have recently presented a simple recipe to construct color-pure blue emitters, which combines basic resonance structure and frontier molecular orbital treatments; this recipe applies to multiresonant type emitters and allows to enlarge the chemical space toward novel structural motifs. In the current work, we show that such fundamental considerations further apply to the structurally entirely different family of xanthene dyes.

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Background: The clinical manifestations of PI4KA-related disorders are characterized by considerable variability, predominantly featuring neurological impairments, gastrointestinal symptoms, and a combined immunodeficiency. The aim of this study was to delineate the novel spectrum of PI4KA variants detected prenatally and to assess their influence on fetal development.

Methods: A thorough fetal ultrasound screening was conducted, supplemented by both antenatal and post-abortion magnetic resonance imaging (MRI) studies.

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Despite considerable social progress, transgender people still face multiple chronic stressors. This study evaluated the allostatic load index and assessed specific psychological characteristics between transgender and cisgender participants who were matched based on age and assigned-at-birth gender. Twenty-one transgender people (52.

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Temporal properties of transcutaneous direct current motor conduction block.

J Neural Eng

January 2025

Physical Medicine and Rehabilitation, The MetroHealth System, 2500 Metrohealth Dr, Cleveland, OH 44109, USA, Cleveland, Ohio, 44109-1998, UNITED STATES.

Direct current (DC) electrical block of peripheral nerve conduction shows promise for clinical applications to treat spasticity, pain, and cardiac arrhythmias. Most previous work has used invasive nerve cuffs. Here we investigate the potential of non-invasive transcutaneous direct current motor block (tDCB).

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Can Focusing on One Deep Learning Architecture Improve Fault Diagnosis Performance?

J Chem Inf Model

January 2025

Department of Chemical and Materials Engineering, Pontifical Catholic University of Rio de Janeiro, 225, Marquês de São Vicente Street, Gávea, Rio de Janeiro, RJ 22451-900, Brazil.

Machine learning approaches often involve evaluating a wide range of models due to various available architectures. This standard strategy can lead to a lack of depth in exploring established methods. In this study, we concentrated our efforts on a single deep learning architecture type to assess whether a focused approach could enhance performance in fault diagnosis.

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