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The karyometric signature is altered in fallopian tubes with serous tubal intraepithelial carcinoma.
Gynecol Oncol
July 2024
University of Arizona, Department of Medicine, Tucson, AZ, United States.
Objective: Recent evidence suggests that the fimbriated end of the fallopian tube harbors the precursor cells for many high-grade ovarian cancers, opening the door for development of better screening methods that directly assess the fallopian tube in women at risk for malignancy. Previously we have shown that the karyometric signature is abnormal in the fallopian tube epithelium in women at hereditary risk of ovarian cancer. In this study, we sought to determine whether the karyometric signature in serous tubal intraepithelial carcinoma (STIC) is significantly different from normal, and whether an abnormal karyometric signature can be detected in histologically normal tubal epithelial cells adjacent to STIC lesions.
View Article and Find Full Text PDFCorrelation of nuclear morphometry of primary melanoma of the skin with clinicopathological parameters and expression of tumor suppressor proteins (p53 and p16(INK4a)) and bcl-2 oncoprotein.
J BUON
November 2013
Institute of Pathology, Faculty of Medicine, University of Nis, Nis, Serbia.
Purpose: To determine the correlation of nuclear morphometry of primary cutaneous malignant melanoma (CMM) with clinicopathological parameters and the expression of p53, p16INK4a, and bcl-2.
Methods: Image analysis and computerized nuclear morphometry were used in a series of 53 primary CMM (nodular melanoma/NM, N=33, and superficially spreading melanoma/SSM, N=20). The clinicopathological parameters determined for each tumor were histological type, maximal tumor diameter, Breslow thickness, Clark level, ulceration, mitotic index (MI) and pathological disease stage.
Regression analysis of the initial karyometric data on tumor cells in ductal carcinoma and fibroadenoma of the mammary gland.
Anal Quant Cytol Histol
April 2010
Laboratory for Electron Paramagnetic Resonance Dosimetry and Cytology, Belarusian State Medical University, Minsk, Belarus.
Objective: To reveal the differences in the parameters of the second order regression curve with a cluster of experimental points on scattergrams showing the dependence of the perimeter on the area of tumor cell nuclei between ductal carcinoma and fibroadenoma of the mammary gland.
Study Design: Punctate smears taken from patients with ductal carcinoma and fibroadenoma of the mammary gland with coincident histologic and cytologic conclusion were studied and selected. Karyometry of tumor cells was performed with the help of a semiautomatic computer analyzer of digital images.
Chemopreventive efficacy of topical difluoromethylornithine and/or triamcinolone in the treatment of actinic keratoses analyzed by karyometry.
Anal Quant Cytol Histol
December 2009
College of Optical Sciences, University of Arizona, Tucson, Arizona 85724-5024, USA.
Objective: To determine whether low-dose topical applications of difluoromethylornithine (DFMO) with or without Triamcinolone (Fougena, Melville, New York, U.S.A.
View Article and Find Full Text PDFPivotal karyometric measurements in different types of cardiomyopathic morphology: study of hearts explanted from transplant recipients.
Transplant Proc
October 2009
Silesian Centre for Heart Diseases, 41-800 Zabrze, Poland.
Background: Morphometric studies based on the measurement of cardiocyte nuclei have focused on progressive hypertrophy rather than shape, which is a deciding factor for the diagnosis of hypertrophy in myocardial diseases. The aim of this research was to demonstrate how the digital morphology of cardiocyte nuclei change correlated with the type of myocardial pathology.
Materials And Methods: The study groups encompassed 7 hearts with dilated cardiomyopathy (DCM) and 8 hearts with ischemic heart disease (IHD) which were explanted.
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