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An Ovarian Sertoli-Leydig Cell Tumor with Elevated Alpha-Fetoprotein in an Adolescent: A Rare Case Report and Literature Review.
Medicina (Kaunas)
September 2024
Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania.
An ovarian Sertoli-Leydig cell tumor is a rare type of sex cord-stromal tumor of the ovary. Typically, it presents as abdominal pain or androgenic manifestations in women in the second to third decade of life. While cases of ovarian Sertoli-Leydig cell tumor associated with increased levels of alpha-fetoprotein are rare, they are reported to be the most common alpha-fetoprotein-producing ovarian non-germ cell tumor.
View Article and Find Full Text PDFGiant Sertoli-Leydig cell tumor of ovary in a 12-year-old girl: An unusual case report.
Asian J Surg
September 2024
School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan Province, 646000, PR China; Department of Emergency, Zigong First People's Hospital, Zigong, Sichuan Province, 643000, PR China. Electronic address:
The role of stathmin expression in the differential diagnosis, prognosis, and potential treatment of ovarian sex cord-stromal tumors.
Diagn Pathol
August 2024
Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studničkova 2, Prague 2, 12800, Czech Republic.
Background: Stathmin, a cytosolic microtubule-destabilizing phosphoprotein involved in the regulation of mitosis, is widely expressed in various malignancies and acts as an adverse prognostic factor. Our research analyzed its immunohistochemical expression on a large cohort of ovarian sex cord-stromal tumors, evaluating its potential utility in differential diagnosis, prognosis, and therapeutic application.
Methods: We examined 390 cases of ovarian sex cord-stromal tumors including 281 adult granulosa cell tumors (AGCT), 5 juvenile granulosa cell tumors (JGCT), 33 Sertoli-Leydig cell tumors (SLCT), 50 fibromas/thecomas (F/T), 11 Leydig cell tumors/steroid cell tumors (LCT/SterCT), 5 sex-cord stromal tumors NOS (SCST-NOS), 3 Sertoli cell tumors (SCT), and 2 sclerosing stromal tumors (ScST).
Sidonia and Nicu de Barcsy: a famous mother with post-partum hirsutism after giving birth to a famous son with idiopathic short stature.
Endocrinol Diabetes Metab Case Rep
July 2024
Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, Dr. Molewaterplein40, Rotterdam, the Netherlands.
Summary: At the end of the 19th century, an 18-year-old lady gave birth to a well-proportioned, though very small, son. After delivery, the mother developed a full-grown beard, whereas the son always remained of small stature. The mother developed diabetes mellitus and died, aged 59, from a complicated severe cold.
View Article and Find Full Text PDFSTK11 (LKB1) immunohistochemistry is a sensitive and specific marker for STK11 adnexal tumours.
Histopathology
November 2024
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- - STK11 adnexal tumours are rare malignant neoplasms associated with Peutz-Jeghers syndrome, primarily arising from para-adnexal soft tissues and potentially affecting the fallopian tube and ovary; diagnosis currently involves identifying STK11 mutations.
- - Researchers conducted immunohistochemistry (IHC) on 122 tumours, including 17 STK11 adnexal tumours and 105 lookalikes; results showed that STK11 adnexal tumours had complete loss of STK11 protein expression, while other tumour types generally retained it.
- - The study concludes that STK11 serves as a sensitive and specific marker for distinguishing STK11 adnexal tumours
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