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Analysis of Changes in Electrolytes Level in Serum After Death and Its Correlation With Postmortem Interval.
Cureus
May 2023
Forensic Medicine, Shaheed Hasan Khan Mewati Government Medical College, Nalhar, Nuh, IND.
Background Apropos estimation of postmortem interval is an important and difficult task for forensic pathologists. In routine practice, postmortem interval is deduced by conventional or physical methods such as early and late postmortem changes, which are subjective methods and prone to errors. Estimating time since death by thanatochemistry is a more objective method as compared to routine conventional or physical methods.
View Article and Find Full Text PDFArsenic-induced genotoxic responses and their amelioration by diphenylene iodonium, 24-epibrassinolide and proline in Glycine max L.
Plant Physiol Biochem
March 2017
School of Studies in Biotechnology, Pt. Ravishankar Shukla University, Raipur 492 010, India. Electronic address:
Presence of the toxic metalloid, "arsenic (As)" is ubiquitous in the environment especially in the soil and water. Its excess availability in the soil retards growth and metabolism of plants via (a) slowing down the cell division/elongation, (b) overproduction of reactive oxygen species (ROS), (c) modulation of antioxidant enzymes, and (d) alteration of DNA profile/genomic template stability (GTS). In the current study, diphenylene iodonium (DPI), 24-epibrassinolide (EBL) and proline (Pro) were used to analyze their roles in eliminating the adverse effects of As.
View Article and Find Full Text PDFpH and salinity evolution of Europa's brines: Raman spectroscopy study of fractional precipitation at 1 and 300 bar.
Astrobiology
August 2013
Departamento de Química Física I, Universidad Complutense de Madrid, Madrid, Spain.
Several lines of evidence indicate the existence of salty liquid water below the icy surface of the satellite Europa. Depending on the chemical composition of the original interior brines, minerals that precipitate will be varied as will be the resulting physicochemical parameters of the evolving solutions such as pH and salinity. These parameters are determinants apropos to the study of the possible habitability of the satellite.
View Article and Find Full Text PDF[Hypokalemic metabolic alkalosis: apropos of a case of Gitelman's syndrome].
Nefrologia
July 2004
Servicio de Nefrología, Hospital Clínico Universitario, Valencia.
We present a case of Gitelman's Syndrome in a 20 year-old woman who came to our service with weakness, asthenia, leg cramps and tetany. Laboratory studies revealed metabolic alkalosis with hypokalemia, hypomagnesemia and low calcium in a 24-hour urine test. The diagnosis of this syndrome is made in some cases during adult life because this syndrome is asymptomatic over several years.
View Article and Find Full Text PDFPhosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain.
Mol Genet Metab
May 2004
Children's Research Institute, Children's National Medical Center, Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
The "inositol depletion hypothesis" has been widely held to be the explanation for both the effect of lithium on brain function, apropos of its use in mood disorders, and on the impairment of development and induction of embryonic malformations in diverse organisms. The essence of the hypothesis is that a deficiency in cellular myo-inositol (Ins), secondary to lithium inhibition of inositol monophosphatase and/or multiple inositol polyphosphate phosphatase activities with trapping of Ins as inositol phosphates, leads to a depression of phosphatidylinositol (PtdIns) and a secondary impairment in inositide signaling. However, the ability of relatively low micromolar levels of Ins to reduce mammalian PtdIns synthetase activity in vivo has never been adequately tested.
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