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Genomic characteristics and molecular epidemiology of MRSA from medical centers in Mexico: Results from the Invifar network.
PLoS One
January 2025
Departamento de Bioquímica y Medicina Molecular, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
Introduction: The methicillin-resistant Staphylococcus aureus (MRSA) genome varies by geographical location. This study aims to determine the genomic characteristics of MRSA using whole-genome sequencing (WGS) data from medical centers in Mexico and to explore the associations between antimicrobial resistance genes and virulence factors.
Methods: This study included 27 clinical isolates collected from sterile sites at eight centers in Mexico in 2022 and 2023.
Nutritional risk and HbA1c as critical risk factors and predictors of opportunistic infections in HIV-DM comorbid patients: a retrospective cross-sectional study.
Front Endocrinol (Lausanne)
January 2025
The First Ward of Internal Medicine, Public Health Clinical Center of Chengdu, Chengdu, China.
Background: The clinical characteristics and risk factors for opportunistic infections in HIV patients with concomitant diabetes mellitus are unclear and worth studying. Explore the risk factors and construct a predictive model for opportunistic infections in HIV-DM patients.
Methods: Clinical data were retrospectively collected from 1,669 HIV-DM admitted to the Public Health Clinical Center of Chengdu from December 2018 to November 2023.
Lipopolysaccharide (LPS) induces sclerostin secretion by extracellular vesicle via TLR4/miR-92a-3p/PTEN/NF-κB signalling pathway in murine macrophage.
Inflamm Res
January 2025
Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, SAR, China.
Background: Sclerostin (SOST) is traditionally regarded as an osteocyte-derived secreted glycoprotein that regulates bone mineralization. Recent studies reported that SOST is also released from non-skeletal sources, especially during inflammation. However, the cellular source and regulatory mechanisms governing SOST generation in inflammation remain unclear.
View Article and Find Full Text PDFMicrobial Biodegradation of Synthetic Polyethylene and Polyurethane Polymers by Pedospheric Microbes: Towards Sustainable Environmental Management.
Polymers (Basel)
January 2025
Institute of Environmental Sciences, Hungarian University of Agriculture and Life Sciences, Páter Károly u. 1, H-2100 Gödöllő, Hungary.
This study attempted to isolate and identify pedospheric microbes originating in dumpsites and utilized them for the degradation of selected synthetic polymers for the first time in a cost-effective, ecologically favorable and sustainable manner. Specifically, low-density polyethylene (LDPE) and polyurethane (PUR) were converted by the isolated fungi, i.e.
View Article and Find Full Text PDFAntibiotic Susceptibility Patterns and Virulence Profiles of Classical and Hypervirulent Strains Isolated from Clinical Samples in Khyber Pakhtunkhwa, Pakistan.
Pathogens
January 2025
Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
The emergence of hypervirulent and carbapenem-resistant hypermucoviscous strains presents a significant public health challenge due to their increased virulence and resistance to multiple antibiotics. This study evaluates the antibiotic susceptibility patterns and virulence profiles of classical and hypervirulent strains isolated from various clinical samples. A total of 500 clinical samples were collected from patients at the Mardan Medical Complex and Ayub Medical Complex in KPK between July 2022 and June 2024.
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